{"id":3956,"date":"2025-04-26T00:37:33","date_gmt":"2025-04-25T21:07:33","guid":{"rendered":"https:\/\/gimed.ir\/gastric-cancer\/?page_id=3956"},"modified":"2025-04-27T00:32:50","modified_gmt":"2025-04-26T21:02:50","slug":"advanced-metastatic-unresectable-oesophageal-oesophagogastric-junction-or-gastric-adenocarcinoma-in-her2-positive-a-escat-i-a-b","status":"publish","type":"page","link":"https:\/\/gimed.ir\/gastric-cancer\/advanced-metastatic-unresectable-oesophageal-oesophagogastric-junction-or-gastric-adenocarcinoma-in-her2-positive-a-escat-i-a-b\/","title":{"rendered":"Advanced\/metastatic unresectable esophageal, esophagogastric junction, or gastric adenocarcinoma in HER2-positive (a) [ESCAT I-A (b)]"},"content":{"rendered":"\t\t
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Advanced\/metastatic unresectable oesophageal, oesophagogastric junction or gastric adenocarcinoma in HER2-positive (a) [ESCAT I-A (b)] <\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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  • \u062f\u0631\u0645\u0627\u0646 \u062e\u0637 \u0627\u0648\u0644 \u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc (ChT) \u0628\u0627 \u062a\u0631\u06a9\u06cc\u0628 \u06cc\u06a9 \u0639\u0627\u0645\u0644 \u067e\u0644\u0627\u062a\u06cc\u0646\u06cc \u0648 \u0641\u0644\u0648\u0626\u0648\u0631\u0648\u067e\u06cc\u0631\u06cc\u0645\u06cc\u062f\u06cc\u0646 \u062a\u0648\u0635\u06cc\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f. \u0627\u06af\u0632\u0627\u0644\u06cc\u200c\u067e\u0644\u0627\u062a\u06cc\u0646 \u0628\u0647\u200c\u0648\u06cc\u0698\u0647 \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0633\u0646\u060c \u06af\u0632\u06cc\u0646\u0647 \u0627\u0631\u062c\u062d \u0627\u0633\u062a (Al-Batran, 2008). \u062f\u0627\u0631\u0648\u06cc S-1 \u0645\u0639\u0645\u0648\u0644\u0627\u064b \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0622\u0633\u06cc\u0627\u06cc\u06cc \u0645\u0648\u0631\u062f \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0642\u0631\u0627\u0631 \u0645\u06cc\u200c\u06af\u06cc\u0631\u062f . (Koizumi, 2008)\u00a0<\/li>
  • \u0628\u0647 \u062f\u0644\u06cc\u0644 \u0633\u0637\u0648\u062d \u0628\u0627\u0644\u0627\u062a\u0631 \u0633\u0645\u06cc\u062a \u0648 \u0639\u062f\u0645 \u0642\u0637\u0639\u06cc\u062a \u062f\u0631 \u0645\u0632\u06cc\u062a \u0628\u0642\u0627 \u0646\u0633\u0628\u062a \u0628\u0647 \u0631\u0698\u06cc\u0645\u200c\u0647\u0627\u06cc \u062f\u0648\u062a\u0627\u06cc\u06cc \u062a\u0648\u0635\u06cc\u0647\u200c\u0634\u062f\u0647\u060c \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u0631\u0698\u06cc\u0645\u200c\u0647\u0627\u06cc \u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc \u0633\u0647\u200c\u062f\u0627\u0631\u0648\u06cc\u06cc \u0645\u0628\u062a\u0646\u06cc \u0628\u0631 \u062a\u0627\u06a9\u0633\u0627\u0646 \u0628\u0647\u200c\u0639\u0646\u0648\u0627\u0646 \u0631\u0648\u06cc\u06a9\u0631\u062f \u0627\u0633\u062a\u0627\u0646\u062f\u0627\u0631\u062f \u062f\u0631 \u062e\u0637 \u0627\u0648\u0644 \u062a\u0648\u0635\u06cc\u0647 \u0646\u0645\u06cc\u200c\u0634\u0648\u062f.<\/li>
  • \u062a\u0631\u06a9\u06cc\u0628 \u0627\u06cc\u0631\u06cc\u0646\u0648\u062a\u06a9\u0627\u0646\u20135-FU \u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u062f \u0628\u0647\u200c\u0639\u0646\u0648\u0627\u0646 \u06cc\u06a9 \u06af\u0632\u06cc\u0646\u0647 \u062c\u0627\u06cc\u06af\u0632\u06cc\u0646 \u0628\u0631\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u0627\u0646\u06cc \u06a9\u0647 \u062a\u062d\u0645\u0644 \u062a\u0631\u06a9\u06cc\u0628\u0627\u062a \u067e\u0644\u0627\u062a\u06cc\u0646\u06cc \u0631\u0627 \u0646\u062f\u0627\u0631\u0646\u062f\u060c \u062f\u0631 \u0646\u0638\u0631 \u06af\u0631\u0641\u062a\u0647 \u0634\u0648\u062f (Dank, 2008; Guimbaud, 2014).<\/li><\/ul>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\n\t\n\t\t\t\t\t\t
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    <\/path><\/svg><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t
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    • \u062a\u0631\u06a9\u06cc\u0628 \u0646\u06cc\u0648\u0648\u0644\u0648\u0645\u0627\u0628\u2013\u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc (ChT) \u0628\u0631\u0627\u06cc \u0622\u062f\u0646\u0648\u06a9\u0627\u0631\u0633\u06cc\u0646\u0648\u0645\u0627\u06cc \u0645\u0639\u062f\u0647\u060c \u0645\u062d\u0644 \u0627\u062a\u0635\u0627\u0644 \u0645\u0631\u06cc-\u0645\u0639\u062f\u0647 (OGJ) \u0648 \u0645\u0631\u06cc\u060c \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0628\u0627 PD-L1 CPS \u22655\u060c \u0628\u0631 \u0627\u0633\u0627\u0633 \u0646\u062a\u0627\u06cc\u062c \u0645\u0637\u0627\u0644\u0639\u0647 CheckMate 649 \u062a\u0648\u0635\u06cc\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f. (Janjigian, 2021)\u00a0<\/li>
    • \u062a\u0631\u06a9\u06cc\u0628 \u067e\u0645\u0628\u0631\u0648\u0644\u06cc\u0632\u0648\u0645\u0627\u0628\u2013\u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc \u0628\u0631\u0627\u06cc \u0622\u062f\u0646\u0648\u06a9\u0627\u0631\u0633\u06cc\u0646\u0648\u0645\u0627\u06cc \u0645\u0639\u062f\u0647 \u0648 OGJ\u060c \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0628\u0627 PD-L1 \u22651\u060c \u0628\u0631 \u0627\u0633\u0627\u0633 \u0646\u062a\u0627\u06cc\u062c \u0645\u0637\u0627\u0644\u0639\u0647 KEYNOTE-859 \u062a\u0648\u0635\u06cc\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f. (Rha, 2023)\u00a0<\/li>
    • \u062a\u0631\u06a9\u06cc\u0628 \u067e\u0645\u0628\u0631\u0648\u0644\u06cc\u0632\u0648\u0645\u0627\u0628\u2013\u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc \u0628\u0631\u0627\u06cc \u0622\u062f\u0646\u0648\u06a9\u0627\u0631\u0633\u06cc\u0646\u0648\u0645\u0627\u06cc \u0645\u0631\u06cc\u060c \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0628\u0627 PD-L1 CPS \u226510\u060c \u0628\u0631 \u0627\u0633\u0627\u0633 \u0646\u062a\u0627\u06cc\u062c \u0645\u0637\u0627\u0644\u0639\u0647 KEYNOTE-590 \u0628\u0627\u06cc\u062f \u0645\u0648\u0631\u062f \u062a\u0648\u062c\u0647 \u0642\u0631\u0627\u0631 \u06af\u06cc\u0631\u062f . (Sun, 2021)<\/li>
    • \u00a0<\/li><\/ul>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\n\t\n\t\t\t\t\t\t
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      <\/path><\/svg><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t
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      • \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 \u062a\u0648\u0645\u0648\u0631\u0647\u0627\u06cc HER2-\u0645\u062b\u0628\u062a\u060c \u062a\u0631\u06a9\u06cc\u0628 \u062a\u0631\u0627\u0633\u062a\u0648\u0632\u0648\u0645\u0627\u0628\u2013\u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc \u062a\u0648\u0635\u06cc\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f.<\/li>
      • \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 \u062a\u0648\u0645\u0648\u0631\u0647\u0627\u06cc HER2-\u0645\u062b\u0628\u062a \u0648 PD-L1 CPS \u22651\u060c \u062a\u0631\u06a9\u06cc\u0628 \u067e\u0645\u0628\u0631\u0648\u0644\u06cc\u0632\u0648\u0645\u0627\u0628\u2013\u062a\u0631\u0627\u0633\u062a\u0648\u0632\u0648\u0645\u0627\u0628\u2013\u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc \u062a\u0648\u0635\u06cc\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f.<\/li>
      • \u00a0<\/li><\/ul>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\n\t\n\t\t\t\t\t\t
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        • \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 \u062a\u0648\u0645\u0648\u0631\u0647\u0627\u06cc HER2-\u0645\u062b\u0628\u062a\u060c \u062a\u0631\u06a9\u06cc\u0628 \u062a\u0631\u0627\u0633\u062a\u0648\u0632\u0648\u0645\u0627\u0628\u2013\u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc \u062a\u0648\u0635\u06cc\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f.<\/li>
        • \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 \u062a\u0648\u0645\u0648\u0631\u0647\u0627\u06cc HER2-\u0645\u062b\u0628\u062a \u0648 PD-L1 CPS \u22651\u060c \u062a\u0631\u06a9\u06cc\u0628 \u067e\u0645\u0628\u0631\u0648\u0644\u06cc\u0632\u0648\u0645\u0627\u0628\u2013\u062a\u0631\u0627\u0633\u062a\u0648\u0632\u0648\u0645\u0627\u0628\u2013\u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc \u062a\u0648\u0635\u06cc\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f.<\/li>
        • \u00a0<\/li><\/ul>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\n\t\n\t\t\t\t\t\t
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          • \u06af\u0627\u0633\u062a\u0631\u06a9\u062a\u0648\u0645\u06cc \u062f\u0631 \u0633\u0631\u0637\u0627\u0646 \u0645\u0639\u062f\u0647 \u0645\u062a\u0627\u0633\u062a\u0627\u062a\u06cc\u06a9\u060c \u0645\u06af\u0631 \u062f\u0631 \u0645\u0648\u0627\u0631\u062f\u06cc \u06a9\u0647 \u0628\u0627 \u0647\u062f\u0641 \u062a\u0633\u06a9\u06cc\u0646 \u0639\u0644\u0627\u0626\u0645 \u0636\u0631\u0648\u0631\u062a \u062f\u0627\u0634\u062a\u0647 \u0628\u0627\u0634\u062f\u060c \u062a\u0648\u0635\u06cc\u0647 \u0646\u0645\u06cc\u200c\u0634\u0648\u062f.<\/li>
          • \u0628\u0631\u062f\u0627\u0634\u062a\u0646 \u0645\u062a\u0627\u0633\u062a\u0627\u0632\u0647\u0627 \u0628\u0647\u200c\u0637\u0648\u0631 \u06a9\u0644\u06cc \u062a\u0648\u0635\u06cc\u0647 \u0646\u0645\u06cc\u200c\u0634\u0648\u062f\u060c \u0627\u0645\u0627 \u0645\u0645\u06a9\u0646 \u0627\u0633\u062a \u0628\u0647\u200c\u0639\u0646\u0648\u0627\u0646 \u06cc\u06a9 \u0631\u0648\u06cc\u06a9\u0631\u062f \u0641\u0631\u062f\u06cc \u062f\u0631 \u0645\u0648\u0627\u0631\u062f \u0628\u0633\u06cc\u0627\u0631 \u062e\u0627\u0635 \u0628\u0627 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0627\u0644\u06cc\u06af\u0648\u0645\u062a\u0627\u0633\u062a\u0627\u062a\u06cc\u06a9 \u0648 \u067e\u0627\u0633\u062e \u0645\u0646\u0627\u0633\u0628 \u0628\u0647 \u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc \u0645\u0648\u0631\u062f \u062a\u0648\u062c\u0647 \u0642\u0631\u0627\u0631 \u06af\u06cc\u0631\u062f.<\/li>
          • \u00a0<\/li><\/ul>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\n\t\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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            <\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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            A) \u0648\u0636\u0639\u06cc\u062a HER2 \u0628\u0647\u200c\u0635\u0648\u0631\u062a IHC 3+ \u06cc\u0627 IHC 2+ \u0647\u0645\u0631\u0627\u0647 \u0628\u0627 FISH \u22652 \u062a\u0639\u0631\u06cc\u0641 \u0645\u06cc\u200c\u0634\u0648\u062f.<\/p>

            B) \u0646\u0645\u0631\u0627\u062a ESCAT \u0641\u0642\u0637 \u0628\u0631\u0627\u06cc \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u0698\u0646\u0648\u0645\u06cc \u06a9\u0627\u0631\u0628\u0631\u062f \u062f\u0627\u0631\u0646\u062f. \u0627\u06cc\u0646 \u0646\u0645\u0631\u0627\u062a \u062a\u0648\u0633\u0637 \u0646\u0648\u06cc\u0633\u0646\u062f\u06af\u0627\u0646 \u062f\u0633\u062a\u0648\u0631\u0627\u0644\u0639\u0645\u0644\u200c\u0647\u0627 \u062a\u0639\u0631\u06cc\u0641 \u0634\u062f\u0647 \u0648 \u062a\u0648\u0633\u0637 ESMO Translational Research and Precision Medicine Working Group** \u0645\u0639\u062a\u0628\u0631\u0633\u0627\u0632\u06cc \u0634\u062f\u0647\u200c\u0627\u0646\u062f. (Mateo, 2018)<\/p>

            C) \u062a\u0631\u06a9\u06cc\u0628\u0627\u062a \u067e\u0644\u0627\u062a\u06cc\u0646 \u062a\u0648\u0635\u06cc\u0647\u200c\u0634\u062f\u0647 \u0634\u0627\u0645\u0644 \u0627\u06af\u0632\u0627\u0644\u06cc\u200c\u067e\u0644\u0627\u062a\u06cc\u0646 \u06cc\u0627 \u0633\u06cc\u0633\u200c\u067e\u0644\u0627\u062a\u06cc\u0646 \u0647\u0633\u062a\u0646\u062f. \u0627\u06af\u0632\u0627\u0644\u06cc\u200c\u067e\u0644\u0627\u062a\u06cc\u0646 \u0628\u0647\u200c\u0648\u06cc\u0698\u0647 \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0633\u0646 \u062a\u0631\u062c\u06cc\u062d \u062f\u0627\u062f\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f. \u0641\u0644\u0648\u0631\u0648\u067e\u06cc\u0631\u06cc\u0645\u06cc\u062f\u06cc\u0646\u200c\u0647\u0627\u06cc \u062a\u0648\u0635\u06cc\u0647\u200c\u0634\u062f\u0647 \u0634\u0627\u0645\u0644 5-FU \u0648\u0631\u06cc\u062f\u06cc, \u06a9\u067e\u0633\u06cc\u062a\u0627\u0628\u06cc\u0646 \u062e\u0648\u0631\u0627\u06a9\u06cc \u06cc\u0627 S-1 \u062e\u0648\u0631\u0627\u06a9\u06cc \u0647\u0633\u062a\u0646\u062f. \u062a\u0631\u06a9\u06cc\u0628 \u0627\u06cc\u0631\u06cc\u0646\u0648\u062a\u06a9\u0627\u0646\u20135-FU \u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u062f \u0628\u0647\u200c\u0639\u0646\u0648\u0627\u0646 \u06cc\u06a9 \u06af\u0632\u06cc\u0646\u0647 \u062c\u0627\u06cc\u06af\u0632\u06cc\u0646 \u0628\u0631\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u0627\u0646\u06cc \u06a9\u0647 \u062a\u0631\u06a9\u06cc\u0628\u0627\u062a \u067e\u0644\u0627\u062a\u06cc\u0646 \u0631\u0627 \u062a\u062d\u0645\u0644 \u0646\u0645\u06cc\u200c\u06a9\u0646\u0646\u062f \u06cc\u0627 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646\u06cc \u06a9\u0647 \u067e\u0633 \u0627\u0632 \u062f\u0631\u0645\u0627\u0646 \u06a9\u0645\u06a9\u06cc \u0628\u0631 \u067e\u0627\u06cc\u0647 \u067e\u0644\u0627\u062a\u06cc\u0646\u060c \u0628\u0647\u200c\u0633\u0631\u0639\u062a \u067e\u06cc\u0634\u0631\u0641\u062a \u0628\u06cc\u0645\u0627\u0631\u06cc \u062f\u0627\u0634\u062a\u0647\u200c\u0627\u0646\u062f\u060c \u062f\u0631 \u0646\u0638\u0631 \u06af\u0631\u0641\u062a\u0647 \u0634\u0648\u062f.<\/p>

            D) \u062a\u0631\u06a9\u06cc\u0628 \u067e\u0645\u0628\u0631\u0648\u0644\u06cc\u0632\u0648\u0645\u0627\u0628\u2013\u062a\u0631\u0627\u0633\u062a\u0648\u0632\u0648\u0645\u0627\u0628\u2013\u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc (ChT \u0647\u0645\u0631\u0627\u0647 \u0628\u0627 \u0641\u0644\u0648\u0631\u0648\u067e\u06cc\u0631\u06cc\u0645\u06cc\u062f\u06cc\u0646 \u0648 \u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc \u062d\u0627\u0648\u06cc \u067e\u0644\u0627\u062a\u06cc\u0646\u060c \u0628\u0631\u0627\u06cc \u062f\u0631\u0645\u0627\u0646 \u062e\u0637 \u0627\u0648\u0644 \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0628\u0632\u0631\u06af\u0633\u0627\u0644 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 \u0622\u062f\u0646\u0648\u06a9\u0627\u0631\u0633\u06cc\u0646\u0648\u0645\u0627\u06cc \u067e\u06cc\u0634\u0631\u0641\u062a\u0647 \u063a\u06cc\u0631\u0642\u0627\u0628\u0644 \u062c\u0631\u0627\u062d\u06cc \u06cc\u0627 \u0645\u062a\u0627\u0633\u062a\u0627\u062a\u06cc\u06a9 HER2-\u0645\u062b\u0628\u062a \u0645\u0639\u062f\u0647 \u06cc\u0627 \u0645\u062d\u0644 \u0627\u062a\u0635\u0627\u0644 \u0645\u0631\u06cc-\u0645\u0639\u062f\u0647 \u06a9\u0647 \u062a\u0648\u0645\u0648\u0631 \u0622\u0646\u200c\u0647\u0627 PD-L1 \u0628\u0627 CPS \u22651 \u0628\u06cc\u0627\u0646 \u0645\u06cc\u200c\u06a9\u0646\u062f\u060c \u062a\u0648\u0635\u06cc\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f. \u0627\u06cc\u0646 \u062a\u0631\u06a9\u06cc\u0628 \u062a\u0648\u0633\u0637 EMA \u0648 FDA \u062a\u0623\u06cc\u06cc\u062f \u0634\u062f\u0647 \u0627\u0633\u062a.<\/p>

            \u0646\u062a\u0627\u06cc\u062c \u0645\u0637\u0627\u0644\u0639\u0647 \u062a\u0635\u0627\u062f\u0641\u06cc\u200c\u0633\u0627\u0632\u06cc\u200c\u0634\u062f\u0647 AIO Intega \u0646\u0634\u0627\u0646\u200c\u062f\u0647\u0646\u062f\u0647 \u0627\u06cc\u0645\u0646\u06cc \u0648 \u0627\u062b\u0631\u0628\u062e\u0634\u06cc \u062a\u0631\u06a9\u06cc\u0628 \u0646\u06cc\u0648\u0644\u0648\u0645\u0627\u0628\u2013\u062a\u0631\u0627\u0633\u062a\u0648\u0632\u0648\u0645\u0627\u0628\u2013FOLFOX \u0627\u0633\u062a\u060c \u0627\u0645\u0627 \u0627\u06cc\u0646 \u0631\u0698\u06cc\u0645 \u0628\u0631\u0627\u06cc \u0627\u06cc\u0646 \u0627\u0646\u062f\u06cc\u06a9\u0627\u0633\u06cc\u0648\u0646 \u062a\u0648\u0633\u0637 EMA \u0648 FDA \u062a\u0623\u06cc\u06cc\u062f \u0646\u0634\u062f\u0647 \u0627\u0633\u062a.<\/p>

            E) \u06af\u0627\u0633\u062a\u0631\u06a9\u062a\u0648\u0645\u06cc \u062f\u0631 \u0633\u0631\u0637\u0627\u0646 \u0645\u0639\u062f\u0647 \u0645\u062a\u0627\u0633\u062a\u0627\u062a\u06cc\u06a9\u060c \u0645\u06af\u0631 \u062f\u0631 \u0645\u0648\u0627\u0631\u062f\u06cc \u06a9\u0647 \u0628\u0627 \u0647\u062f\u0641 \u062a\u0633\u06a9\u06cc\u0646 \u0639\u0644\u0627\u0626\u0645 \u0627\u0646\u062c\u0627\u0645 \u0634\u0648\u062f\u060c \u062a\u0648\u0635\u06cc\u0647 \u0646\u0645\u06cc\u200c\u0634\u0648\u062f.<\/p>

            F) \u0628\u0631\u062f\u0627\u0634\u062a \u0645\u062a\u0627\u0633\u062a\u0627\u0632\u0647\u0627 \u0648 \u062c\u0631\u0627\u062d\u06cc \u06a9\u0627\u0647\u0646\u062f\u0647 \u062a\u0648\u062f\u0647 (Cytoreductive Surgery) \u062f\u0631 \u0645\u062a\u0627\u0633\u062a\u0627\u0632\u0647\u0627\u06cc \u0635\u0641\u0627\u0642\u06cc\u060c \u0628\u0647\u200c\u0637\u0648\u0631 \u06a9\u0644\u06cc \u062a\u0648\u0635\u06cc\u0647 \u0646\u0645\u06cc\u200c\u0634\u0648\u062f\u060c \u0627\u0645\u0627 \u062f\u0631 \u0645\u0648\u0627\u0631\u062f \u0628\u0633\u06cc\u0627\u0631 \u0627\u0646\u062a\u062e\u0627\u0628\u200c\u0634\u062f\u0647\u060c \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0627\u0644\u06cc\u06af\u0648\u0645\u062a\u0627\u0633\u062a\u0627\u062a\u06cc\u06a9 \u0648 \u067e\u0627\u0633\u062e \u0628\u0647 \u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc\u060c \u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u062f \u0628\u0647\u200c\u0639\u0646\u0648\u0627\u0646 \u06cc\u06a9 \u0631\u0648\u06cc\u06a9\u0631\u062f \u0641\u0631\u062f\u06cc \u062f\u0631 \u0646\u0638\u0631 \u06af\u0631\u0641\u062a\u0647 \u0634\u0648\u062f. \u062f\u0631 \u0645\u0637\u0627\u0644\u0639\u0647 Renaissance trial\u060c \u0627\u0641\u0632\u0648\u062f\u0646 \u0628\u0631\u062f\u0627\u0634\u062a \u0645\u062a\u0627\u0633\u062a\u0627\u0632\u0647\u0627 \u0628\u0647 \u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc \u0633\u06cc\u0633\u062a\u0645\u06cc\u06a9\u060c \u0628\u0642\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0631\u0627 \u0628\u0647\u0628\u0648\u062f \u0646\u0628\u062e\u0634\u06cc\u062f. \u0647\u0645\u0686\u0646\u06cc\u0646\u060c \u062c\u0631\u0627\u062d\u06cc \u06a9\u0627\u0647\u0646\u062f\u0647 \u062a\u0648\u062f\u0647 \u062f\u0631 \u0645\u062a\u0627\u0633\u062a\u0627\u0632\u0647\u0627\u06cc \u0635\u0641\u0627\u0642\u06cc \u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u062f \u0632\u06cc\u0627\u0646\u200c\u0628\u0627\u0631 \u0628\u0627\u0634\u062f.<\/p>

            \u0627\u0633\u062a\u0627\u0646\u062f\u0627\u0631\u062f \u062f\u0631\u0645\u0627\u0646 \u0628\u0631\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u06cc \u0645\u0631\u062d\u0644\u0647 IV\u060c \u062f\u0631\u0645\u0627\u0646 \u0633\u06cc\u0633\u062a\u0645\u06cc\u06a9 \u0628\u0627 \u06cc\u06a9 \u0631\u0698\u06cc\u0645 \u0645\u0639\u062a\u0628\u0631 \u0648 \u062a\u0648\u0635\u06cc\u0647\u200c\u0634\u062f\u0647 \u0627\u0633\u062a. \u062c\u0631\u0627\u062d\u06cc \u062e\u0627\u0631\u062c \u0627\u0632 \u0686\u0627\u0631\u0686\u0648\u0628 \u06cc\u06a9 \u06a9\u0627\u0631\u0622\u0632\u0645\u0627\u06cc\u06cc \u0628\u0627\u0644\u06cc\u0646\u06cc \u06cc\u0627 \u062f\u0631 \u0645\u0648\u0627\u0631\u062f \u0628\u0633\u06cc\u0627\u0631 \u0627\u0646\u062a\u062e\u0627\u0628\u200c\u0634\u062f\u0647\u060c \u062a\u0646\u0647\u0627 \u067e\u0633 \u0627\u0632 \u06cc\u06a9 \u062f\u0648\u0631\u0647 \u0637\u0648\u0644\u0627\u0646\u06cc\u200c\u0645\u062f\u062a \u062f\u0631\u0645\u0627\u0646 \u0633\u06cc\u0633\u062a\u0645\u06cc\u06a9 (\u0627\u0633\u062a\u0627\u0646\u062f\u0627\u0631\u062f \u062f\u0631\u0645\u0627\u0646) \u0648 \u067e\u0633 \u0627\u0632 \u0628\u0631\u0631\u0633\u06cc \u062f\u0642\u06cc\u0642 \u062f\u0631 \u06cc\u06a9 \u062a\u0648\u0645\u0648\u0631\u0628\u0648\u0631\u062f \u0686\u0646\u062f\u062a\u062e\u0635\u0635\u06cc \u062f\u0631 \u06cc\u06a9 \u0645\u0631\u06a9\u0632 \u0627\u0631\u062c\u0627\u0639\u06cc \u062b\u0627\u0644\u062b \u0628\u0627 \u062d\u062c\u0645 \u0628\u0627\u0644\u0627 \u062a\u0648\u0635\u06cc\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

            Advanced\/metastatic unresectable oesophageal, oesophagogastric junction or gastric adenocarcinoma in HER2-positive (a) [ESCAT I-A (b)] \u062f\u0631\u0645\u0627\u0646 \u062e\u0637 \u0627\u0648\u0644 \u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc (ChT) \u0628\u0627 \u062a\u0631\u06a9\u06cc\u0628 \u06cc\u06a9 \u0639\u0627\u0645\u0644 \u067e\u0644\u0627\u062a\u06cc\u0646\u06cc \u0648 \u0641\u0644\u0648\u0626\u0648\u0631\u0648\u067e\u06cc\u0631\u06cc\u0645\u06cc\u062f\u06cc\u0646 \u062a\u0648\u0635\u06cc\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f. \u0627\u06af\u0632\u0627\u0644\u06cc\u200c\u067e\u0644\u0627\u062a\u06cc\u0646 \u0628\u0647\u200c\u0648\u06cc\u0698\u0647 \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0633\u0646\u060c \u06af\u0632\u06cc\u0646\u0647 \u0627\u0631\u062c\u062d \u0627\u0633\u062a (Al-Batran, 2008). \u062f\u0627\u0631\u0648\u06cc S-1 \u0645\u0639\u0645\u0648\u0644\u0627\u064b \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0622\u0633\u06cc\u0627\u06cc\u06cc \u0645\u0648\u0631\u062f \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0642\u0631\u0627\u0631 \u0645\u06cc\u200c\u06af\u06cc\u0631\u062f . (Koizumi, 2008)\u00a0 \u0628\u0647 \u062f\u0644\u06cc\u0644 \u0633\u0637\u0648\u062d \u0628\u0627\u0644\u0627\u062a\u0631 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3956","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/gimed.ir\/gastric-cancer\/wp-json\/wp\/v2\/pages\/3956","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gimed.ir\/gastric-cancer\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/gimed.ir\/gastric-cancer\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/gimed.ir\/gastric-cancer\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/gimed.ir\/gastric-cancer\/wp-json\/wp\/v2\/comments?post=3956"}],"version-history":[{"count":14,"href":"https:\/\/gimed.ir\/gastric-cancer\/wp-json\/wp\/v2\/pages\/3956\/revisions"}],"predecessor-version":[{"id":3991,"href":"https:\/\/gimed.ir\/gastric-cancer\/wp-json\/wp\/v2\/pages\/3956\/revisions\/3991"}],"wp:attachment":[{"href":"https:\/\/gimed.ir\/gastric-cancer\/wp-json\/wp\/v2\/media?parent=3956"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}