
{"id":4365,"date":"2025-09-01T20:50:51","date_gmt":"2025-09-01T17:20:51","guid":{"rendered":"https:\/\/gimed.ir\/Colorectal-cancer\/?p=4365"},"modified":"2025-09-01T21:06:54","modified_gmt":"2025-09-01T17:36:54","slug":"diagnosis-pathology-and-molecular-biology","status":"publish","type":"post","link":"https:\/\/gimed.ir\/Colorectal-cancer\/diagnosis-pathology-and-molecular-biology\/","title":{"rendered":"Diagnosis, pathology and molecular biology"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"4365\" class=\"elementor elementor-4365\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-13901c6 e-flex e-con-boxed e-con e-parent\" data-id=\"13901c6\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-fef3638 e-con-full e-flex e-con e-child\" data-id=\"fef3638\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-66ba091 e-con-full e-flex e-con e-child\" data-id=\"66ba091\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-18daca4 elementor-widget elementor-widget-text-editor\" data-id=\"18daca4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p style=\"text-align: right;\"><b>\u062a\u0634\u062e\u06cc\u0635\u060c \u067e\u0627\u062a\u0648\u0644\u0648\u0698\u06cc \u0648 \u0632\u06cc\u0633\u062a\u200c\u0634\u0646\u0627\u0633\u06cc \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc<\/b><\/p><ul><li style=\"text-align: right;\">\u0628\u0631\u0627\u06cc \u0622\u0632\u0645\u0627\u06cc\u0634\u200c\u0647\u0627\u06cc \u0646\u0634\u0627\u0646\u06af\u0631 \u0632\u06cc\u0633\u062a\u06cc (Biomarker) \u062a\u0648\u0635\u06cc\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f \u06a9\u0647 \u0646\u0645\u0648\u0646\u0647\u200c\u0647\u0627 \u0628\u0627 \u0641\u0631\u0645\u0627\u0644\u06cc\u0646 \u0628\u0627\u0641\u0631\u06cc \u062e\u0646\u062b\u06cc \u06f1\u06f0\u066a (\u0645\u0639\u0627\u062f\u0644 \u06f4\u066a \u0641\u0631\u0645\u0627\u0644\u062f\u0647\u06cc\u062f) \u062a\u062b\u0628\u06cc\u062a \u0634\u0648\u0646\u062f\u061b \u0645\u062f\u062a \u062a\u062b\u0628\u06cc\u062a \u0646\u0628\u0627\u06cc\u062f \u06a9\u0645\u062a\u0631 \u0627\u0632 \u06f6 \u0633\u0627\u0639\u062a \u0648 \u0628\u06cc\u0634\u062a\u0631 \u0627\u0632 \u06f4\u06f8 \u0633\u0627\u0639\u062a \u0628\u0627\u0634\u062f. (\u062f\u0631\u062c\u0647 \u062a\u0648\u0635\u06cc\u0647: V, A)<\/li><li style=\"text-align: right;\">\u067e\u0627\u062a\u0648\u0644\u0648\u0698\u06cc\u0633\u062a \u0627\u0635\u0644\u06cc \u0628\u0627\u06cc\u062f \u062a\u0645\u0627\u0645 \u0646\u0645\u0648\u0646\u0647\u200c\u0647\u0627\u06cc \u062a\u0648\u0645\u0648\u0631\u06cc \u0645\u0648\u062c\u0648\u062f \u0631\u0627 \u0628\u0631\u0631\u0633\u06cc \u06a9\u0646\u062f \u0648 \u0628\u0631\u0627\u06cc \u0627\u0641\u0632\u0627\u06cc\u0634 \u0645\u062d\u062a\u0648\u0627\u06cc \u0633\u0644\u0648\u0644\u200c\u0647\u0627\u06cc \u062a\u0648\u0645\u0648\u0631\u06cc (\u0628\u06cc\u0634 \u0627\u0632 \u06f2\u06f0\u066a) \u067e\u06cc\u0634 \u0627\u0632 \u0627\u0633\u062a\u062e\u0631\u0627\u062c DNA\u060c \u0627\u0632 \u0631\u0648\u0634 \u0645\u0627\u06a9\u0631\u0648-\u062f\u06cc\u0633\u0650\u06a9\u0634\u0646 <b>(<\/b><b>Macro-dissection<\/b><b>)<\/b> \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0646\u0645\u0627\u06cc\u062f. (IV, A)<\/li><li style=\"text-align: right;\">\u062f\u0631 \u062a\u0645\u0627\u0645 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u062f\u0631 \u0632\u0645\u0627\u0646 \u062a\u0634\u062e\u06cc\u0635 \u0633\u0631\u0637\u0627\u0646 \u06a9\u0648\u0644\u0648\u0631\u06a9\u062a\u0627\u0644 \u0645\u062a\u0627\u0633\u062a\u0627\u062a\u06cc\u06a9\u060c \u0627\u0646\u062c\u0627\u0645 \u062a\u0633\u062a \u0628\u0631\u0627\u06cc:<\/li><li style=\"text-align: right;\"><b>\u0648\u0636\u0639\u06cc\u062a <\/b><b>MMR<\/b> (\u062f\u0631 \u0635\u0648\u0631\u062a \u0634\u0646\u0627\u0633\u0627\u06cc\u06cc \u0628\u0627 NGS\u061b ESCAT: I-A)<\/li><li style=\"text-align: right;\"><b>\u062c\u0647\u0634\u200c\u0647\u0627\u06cc <\/b><b><\/b><b>KRAS <\/b><b>\u0648 <\/b><b><\/b><b>NRAS <\/b><b>(\u0627\u06af\u0632\u0648\u0646\u200c\u0647\u0627\u06cc \u06f2\u060c \u06f3 \u0648 \u06f4)<\/b><\/li><li style=\"text-align: right;\"><b>\u062c\u0647\u0634 <\/b><b>BRAF<\/b> (ESCAT: I-A)<br \/>\u062a\u0648\u0635\u06cc\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f. (I, A)<\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c3057d0 e-con-full e-flex e-con e-child\" data-id=\"c3057d0\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5dc28de e-flex e-con-boxed e-con e-parent\" data-id=\"5dc28de\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3f545fd e-con-full e-flex e-con e-child\" data-id=\"3f545fd\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3f04f0b e-con-full e-flex e-con e-child\" data-id=\"3f04f0b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-68d6ecd elementor-widget elementor-widget-hotspot\" data-id=\"68d6ecd\" data-element_type=\"widget\" data-settings=\"{&quot;hotspot&quot;:[{&quot;_id&quot;:&quot;6490865&quot;,&quot;hotspot_icon&quot;:{&quot;value&quot;:&quot;fas fa-info-circle&quot;,&quot;library&quot;:&quot;fa-solid&quot;},&quot;hotspot_custom_size&quot;:&quot;&quot;,&quot;hotspot_tooltip_content&quot;:&quot;&lt;h4 style=\\&quot;text-align: center;\\&quot;&gt;\\u0628\\u06cc\\u0645\\u0627\\u0631\\u0627\\u0646 \\u0636\\u0639\\u06cc\\u0641 \\u0648\\\/\\u06cc\\u0627 \\u062f\\u0627\\u0631\\u0627\\u06cc \\u0628\\u06cc\\u0645\\u0627\\u0631\\u06cc\\u200c\\u0647\\u0627\\u06cc \\u0647\\u0645\\u0631\\u0627\\u0647&lt;\\\/h4&gt;&lt;ul&gt;&lt;li&gt;\\u062a\\u0639\\u06cc\\u06cc\\u0646 \\u0648\\u0636\\u0639\\u06cc\\u062a \\u062c\\u0647\\u0634RAS \\u0627\\u0632 \\u0637\\u0631\\u06cc\\u0642 \\u0646\\u0645\\u0648\\u0646\\u0647\\u200c\\u0628\\u0631\\u062f\\u0627\\u0631\\u06cc \\u062a\\u0648\\u0645\\u0648\\u0631 [I, A] (\\u06cc\\u0627 \\u0627\\u0632 \\u0637\\u0631\\u06cc\\u0642 \\u0646\\u0645\\u0648\\u0646\\u0647\\u200c\\u0628\\u0631\\u062f\\u0627\\u0631\\u06cc \\u0645\\u0627\\u06cc\\u0639 \\u062f\\u0631 \\u0635\\u0648\\u0631\\u062a \\u0639\\u062f\\u0645 \\u062f\\u0633\\u062a\\u0631\\u0633\\u06cc \\u0628\\u0647 \\u0646\\u0645\\u0648\\u0646\\u0647 \\u062a\\u0648\\u0645\\u0648\\u0631 [II, B]) \\u0628\\u0631\\u0627\\u06cc \\u0647\\u062f\\u0627\\u06cc\\u062a \\u0628\\u0647\\u062a\\u0631\\u06cc\\u0646 \\u062a\\u0635\\u0645\\u06cc\\u0645 \\u062f\\u0631\\u0645\\u0627\\u0646\\u06cc \\u0627\\u0644\\u0632\\u0627\\u0645\\u06cc \\u0627\\u0633\\u062a.\\u00a0&lt;\\\/li&gt;&lt;li&gt;\\u062f\\u0631 \\u0628\\u06cc\\u0645\\u0627\\u0631\\u0627\\u0646\\u06cc \\u06a9\\u0647 \\u062f\\u0627\\u0631\\u0627\\u06cc \\u0628\\u06cc\\u0645\\u0627\\u0631\\u06cc\\u200c\\u0647\\u0627\\u06cc \\u0647\\u0645\\u0631\\u0627\\u0647\\u060c \\u0633\\u0646 \\u0628\\u0627\\u0644\\u0627 \\u06cc\\u0627 \\u0628\\u06cc\\u0645\\u0627\\u0631\\u06cc \\u0645\\u062a\\u0627\\u0633\\u062a\\u0627\\u062a\\u06cc\\u06a9 \\u0647\\u0633\\u062a\\u0646\\u062f \\u06a9\\u0647 \\u0642\\u0627\\u0628\\u0644 \\u062f\\u0631\\u0645\\u0627\\u0646 \\u0628\\u0647 \\u0631\\u0648\\u0634\\u200c\\u0647\\u0627\\u06cc \\u0642\\u0637\\u0639\\u06cc \\u0646\\u0628\\u0648\\u062f\\u0647 \\u0648 \\u0639\\u0644\\u0627\\u0626\\u0645 \\u0642\\u0627\\u0628\\u0644 \\u062a\\u0648\\u062c\\u0647\\u06cc \\u0627\\u0632 \\u0628\\u06cc\\u0645\\u0627\\u0631\\u06cc \\u0646\\u062f\\u0627\\u0631\\u0646\\u062f\\u060c \\u0627\\u0633\\u062a\\u0641\\u0627\\u062f\\u0647 \\u0627\\u0632 \\u062f\\u0631\\u0645\\u0627\\u0646 \\u062a\\u06a9\\u200c\\u062f\\u0627\\u0631\\u0648\\u06cc\\u06cc \\u0628\\u0627 \\u0641\\u0644\\u0648\\u0631\\u0648\\u067e\\u06cc\\u0631\\u0645\\u06cc\\u062f\\u06cc\\u0646 \\u00b1 \\u0628\\u0648\\u0627\\u0633\\u06cc\\u0632\\u0648\\u0645\\u0627\\u0628 \\u0642\\u0627\\u0628\\u0644 \\u0627\\u0633\\u062a\\u0641\\u0627\\u062f\\u0647 \\u0627\\u0633\\u062a [I, B]. \\u062f\\u0631 \\u0628\\u06cc\\u0645\\u0627\\u0631\\u0627\\u0646 \\u0636\\u0639\\u06cc\\u0641 \\u06cc\\u0627 \\u0645\\u0633\\u0646 \\u06a9\\u0647 \\u0642\\u0627\\u062f\\u0631 \\u0628\\u0647 \\u062a\\u062d\\u0645\\u0644 \\u0634\\u06cc\\u0645\\u06cc\\u200c\\u062f\\u0631\\u0645\\u0627\\u0646\\u06cc \\u0646\\u06cc\\u0633\\u062a\\u0646\\u062f \\u0648 \\u062a\\u0648\\u0645\\u0648\\u0631\\u0647\\u0627\\u06cc\\u0634\\u0627\\u0646 \\u0633\\u0645\\u062a \\u0686\\u067e \\u0648 RAS-wt \\u0627\\u0633\\u062a\\u060c \\u062f\\u0631\\u0645\\u0627\\u0646 \\u062a\\u06a9\\u200c\\u062f\\u0627\\u0631\\u0648\\u06cc\\u06cc \\u0628\\u0627 \\u0622\\u0646\\u062a\\u06cc\\u200c\\u0628\\u0627\\u062f\\u06cc\\u200c\\u0647\\u0627\\u06cc \\u0645\\u0648\\u0646\\u0648\\u06a9\\u0644\\u0648\\u0646\\u0627\\u0644 \\u0636\\u062f-EGFR \\u0645\\u06cc\\u200c\\u062a\\u0648\\u0627\\u0646\\u062f \\u062f\\u0631 \\u0646\\u0638\\u0631 \\u06af\\u0631\\u0641\\u062a\\u0647 \\u0634\\u0648\\u062f [IV, C].&lt;\\\/li&gt;&lt;li&gt;\\u062f\\u0631 \\u0628\\u06cc\\u0645\\u0627\\u0631\\u0627\\u0646\\u06cc \\u06a9\\u0647 \\u062f\\u0631 \\u0627\\u062b\\u0631 \\u0634\\u06cc\\u0645\\u06cc\\u200c\\u062f\\u0631\\u0645\\u0627\\u0646\\u06cc \\u0645\\u0628\\u062a\\u0646\\u06cc \\u0628\\u0631 5-FU \\u06cc\\u0627 \\u06a9\\u0627\\u067e\\u0633\\u06cc\\u062a\\u0627\\u0628\\u06cc\\u0646 \\u062f\\u0686\\u0627\\u0631 \\u0633\\u0645\\u06cc\\u062a \\u0642\\u0644\\u0628\\u06cc \\u0648\\\/\\u06cc\\u0627 \\u0633\\u0646\\u062f\\u0631\\u0645 \\u062f\\u0633\\u062a \\u0648 \\u067e\\u0627 \\u0634\\u062f\\u0647\\u200c\\u0627\\u0646\\u062f\\u060c \\u0645\\u06cc\\u200c\\u062a\\u0648\\u0627\\u0646 \\u0627\\u0632S-1 \\u0628\\u0647 \\u0639\\u0646\\u0648\\u0627\\u0646 \\u062c\\u0627\\u06cc\\u06af\\u0632\\u06cc\\u0646 \\u0627\\u0633\\u062a\\u0641\\u0627\\u062f\\u0647 \\u06a9\\u0631\\u062f [III, B].&lt;\\\/li&gt;&lt;\\\/ul&gt;&quot;,&quot;hotspot_offset_x&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:52,&quot;sizes&quot;:[]},&quot;hotspot_offset_y&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:26,&quot;sizes&quot;:[]},&quot;hotspot_tooltip_position&quot;:&quot;yes&quot;,&quot;hotspot_position&quot;:&quot;top&quot;,&quot;hotspot_tooltip_width&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:409,&quot;sizes&quot;:[]},&quot;hotspot_tooltip_text_wrap&quot;:&quot;yes&quot;,&quot;hotspot_label&quot;:&quot;&quot;,&quot;hotspot_link&quot;:{&quot;url&quot;:&quot;&quot;,&quot;is_external&quot;:&quot;&quot;,&quot;nofollow&quot;:&quot;&quot;,&quot;custom_attributes&quot;:&quot;&quot;},&quot;hotspot_horizontal&quot;:&quot;right&quot;,&quot;hotspot_vertical&quot;:&quot;top&quot;}],&quot;tooltip_position&quot;:&quot;right&quot;,&quot;hotspot_sequenced_animation&quot;:&quot;no&quot;,&quot;tooltip_trigger&quot;:&quot;click&quot;,&quot;tooltip_animation&quot;:&quot;e-hotspot--fade-in-out&quot;}\" data-widget_type=\"hotspot.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"378\" src=\"https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2025\/09\/0001-1200x567.png\" class=\"attachment-large size-large wp-image-4369\" alt=\"\" srcset=\"https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2025\/09\/0001-1200x567.png 1200w, https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2025\/09\/0001-500x236.png 500w, https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2025\/09\/0001-300x142.png 300w, https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2025\/09\/0001-768x363.png 768w, https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2025\/09\/0001.png 1235w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\n\t\t\t\t\t\t<div class=\"e-hotspot elementor-repeater-item-6490865  e-hotspot--position-right e-hotspot--position-top   e-hotspot--icon\">\n\n\t\t\t\t\t\t\t\t<div class=\"e-hotspot__button e-hotspot--soft-beat\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__icon\"><svg class=\"e-font-icon-svg e-fas-info-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z\"><\/path><\/svg><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__tooltip  e-hotspot--tooltip-position e-hotspot--fade-in-out \" >\n\t\t\t\t\t\t<h4 style=\"text-align: center;\">\u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0636\u0639\u06cc\u0641 \u0648\/\u06cc\u0627 \u062f\u0627\u0631\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u06cc\u200c\u0647\u0627\u06cc \u0647\u0645\u0631\u0627\u0647<\/h4><ul><li>\u062a\u0639\u06cc\u06cc\u0646 \u0648\u0636\u0639\u06cc\u062a \u062c\u0647\u0634RAS \u0627\u0632 \u0637\u0631\u06cc\u0642 \u0646\u0645\u0648\u0646\u0647\u200c\u0628\u0631\u062f\u0627\u0631\u06cc \u062a\u0648\u0645\u0648\u0631 [I, A] (\u06cc\u0627 \u0627\u0632 \u0637\u0631\u06cc\u0642 \u0646\u0645\u0648\u0646\u0647\u200c\u0628\u0631\u062f\u0627\u0631\u06cc \u0645\u0627\u06cc\u0639 \u062f\u0631 \u0635\u0648\u0631\u062a \u0639\u062f\u0645 \u062f\u0633\u062a\u0631\u0633\u06cc \u0628\u0647 \u0646\u0645\u0648\u0646\u0647 \u062a\u0648\u0645\u0648\u0631 [II, B]) \u0628\u0631\u0627\u06cc \u0647\u062f\u0627\u06cc\u062a \u0628\u0647\u062a\u0631\u06cc\u0646 \u062a\u0635\u0645\u06cc\u0645 \u062f\u0631\u0645\u0627\u0646\u06cc \u0627\u0644\u0632\u0627\u0645\u06cc \u0627\u0633\u062a.\u00a0<\/li><li>\u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646\u06cc \u06a9\u0647 \u062f\u0627\u0631\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u06cc\u200c\u0647\u0627\u06cc \u0647\u0645\u0631\u0627\u0647\u060c \u0633\u0646 \u0628\u0627\u0644\u0627 \u06cc\u0627 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0645\u062a\u0627\u0633\u062a\u0627\u062a\u06cc\u06a9 \u0647\u0633\u062a\u0646\u062f \u06a9\u0647 \u0642\u0627\u0628\u0644 \u062f\u0631\u0645\u0627\u0646 \u0628\u0647 \u0631\u0648\u0634\u200c\u0647\u0627\u06cc \u0642\u0637\u0639\u06cc \u0646\u0628\u0648\u062f\u0647 \u0648 \u0639\u0644\u0627\u0626\u0645 \u0642\u0627\u0628\u0644 \u062a\u0648\u062c\u0647\u06cc \u0627\u0632 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0646\u062f\u0627\u0631\u0646\u062f\u060c \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u062f\u0631\u0645\u0627\u0646 \u062a\u06a9\u200c\u062f\u0627\u0631\u0648\u06cc\u06cc \u0628\u0627 \u0641\u0644\u0648\u0631\u0648\u067e\u06cc\u0631\u0645\u06cc\u062f\u06cc\u0646 \u00b1 \u0628\u0648\u0627\u0633\u06cc\u0632\u0648\u0645\u0627\u0628 \u0642\u0627\u0628\u0644 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0633\u062a [I, B]. \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0636\u0639\u06cc\u0641 \u06cc\u0627 \u0645\u0633\u0646 \u06a9\u0647 \u0642\u0627\u062f\u0631 \u0628\u0647 \u062a\u062d\u0645\u0644 \u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc \u0646\u06cc\u0633\u062a\u0646\u062f \u0648 \u062a\u0648\u0645\u0648\u0631\u0647\u0627\u06cc\u0634\u0627\u0646 \u0633\u0645\u062a \u0686\u067e \u0648 RAS-wt \u0627\u0633\u062a\u060c \u062f\u0631\u0645\u0627\u0646 \u062a\u06a9\u200c\u062f\u0627\u0631\u0648\u06cc\u06cc \u0628\u0627 \u0622\u0646\u062a\u06cc\u200c\u0628\u0627\u062f\u06cc\u200c\u0647\u0627\u06cc \u0645\u0648\u0646\u0648\u06a9\u0644\u0648\u0646\u0627\u0644 \u0636\u062f-EGFR \u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u062f \u062f\u0631 \u0646\u0638\u0631 \u06af\u0631\u0641\u062a\u0647 \u0634\u0648\u062f [IV, C].<\/li><li>\u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646\u06cc \u06a9\u0647 \u062f\u0631 \u0627\u062b\u0631 \u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc \u0645\u0628\u062a\u0646\u06cc \u0628\u0631 5-FU \u06cc\u0627 \u06a9\u0627\u067e\u0633\u06cc\u062a\u0627\u0628\u06cc\u0646 \u062f\u0686\u0627\u0631 \u0633\u0645\u06cc\u062a \u0642\u0644\u0628\u06cc \u0648\/\u06cc\u0627 \u0633\u0646\u062f\u0631\u0645 \u062f\u0633\u062a \u0648 \u067e\u0627 \u0634\u062f\u0647\u200c\u0627\u0646\u062f\u060c \u0645\u06cc\u200c\u062a\u0648\u0627\u0646 \u0627\u0632S-1 \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u062c\u0627\u06cc\u06af\u0632\u06cc\u0646 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u06a9\u0631\u062f [III, B].<\/li><\/ul>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\n\t\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5db61c1 e-con-full e-flex e-con e-child\" data-id=\"5db61c1\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-51d3b9c e-flex e-con-boxed e-con e-parent\" data-id=\"51d3b9c\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3963929 e-con-full e-flex e-con e-child\" data-id=\"3963929\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c2eb875 e-con-full e-flex e-con e-child\" data-id=\"c2eb875\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-531a0c7 elementor-widget elementor-widget-text-editor\" data-id=\"531a0c7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li style=\"text-align: right;\"><b>\u0622\u0632\u0645\u0627\u06cc\u0634<\/b><b> RAS<\/b> \u067e\u06cc\u0634 \u0627\u0632 \u062f\u0631\u0645\u0627\u0646 \u0628\u0627 \u0622\u0646\u062a\u06cc\u200c\u0628\u0627\u062f\u06cc\u200c\u0647\u0627\u06cc \u0645\u0648\u0646\u0648\u06a9\u0644\u0648\u0646\u0627\u0644 \u0636\u062f EGFR \u0627\u0644\u0632\u0627\u0645\u06cc \u0627\u0633\u062a \u0648 \u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u062f \u0647\u0645 \u0628\u0631 \u0631\u0648\u06cc \u062a\u0648\u0645\u0648\u0631 \u0627\u0648\u0644\u06cc\u0647 \u0648 \u0647\u0645 \u0628\u0631 \u0631\u0648\u06cc \u0645\u062a\u0627\u0633\u062a\u0627\u0632\u0647\u0627 \u0627\u0646\u062c\u0627\u0645 \u0634\u0648\u062f. \u3010III, A\u3011<\/li><li style=\"text-align: right;\">\u0628\u0631\u0631\u0633\u06cc \u0648\u0636\u0639\u06cc\u062a <b>\u062c\u0647\u0634<\/b><b> BRAF V600E <\/b>(ESCAT: I-A) \u0628\u0627\u06cc\u062f \u0647\u0645\u0632\u0645\u0627\u0646 \u0628\u0627 RAS \u0627\u0646\u062c\u0627\u0645 \u0634\u0648\u062f\u060c \u0628\u0631\u0627\u06cc:<\/li><li style=\"text-align: right;\"><b>\u0627\u0631\u0632\u06cc\u0627\u0628\u06cc \u067e\u06cc\u0634\u200c\u0622\u06af\u0647\u06cc<\/b><b> (Prognosis)<\/b> (I, B)<\/li><li style=\"text-align: right;\">\u0648 \u0646\u06cc\u0632 \u0627\u0645\u06a9\u0627\u0646 \u0627\u0646\u062a\u062e\u0627\u0628 <b>\u062f\u0631\u0645\u0627\u0646\u200c\u0647\u0627\u06cc \u0647\u062f\u0641\u0645\u0646\u062f<\/b><b> (Targeted therapy<\/b><b>)<\/b>.<\/li><li style=\"text-align: right;\">\u0622\u0632\u0645\u0627\u06cc\u0634 <b>DMMR\/MSI-H<\/b> (ESCAT: I-A\u060c \u062f\u0631 \u0635\u0648\u0631\u062a \u0634\u0646\u0627\u0633\u0627\u06cc\u06cc \u0628\u0627 NGS) \u062f\u0631 \u0633\u0631\u0637\u0627\u0646 \u06a9\u0648\u0644\u0648\u0631\u06a9\u062a\u0627\u0644 \u0645\u062a\u0627\u0633\u062a\u0627\u062a\u06cc\u06a9:<\/li><li style=\"text-align: right;\">\u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u062f \u062f\u0631 \u0645\u0634\u0627\u0648\u0631\u0647 \u0698\u0646\u062a\u06cc\u06a9\u06cc \u0628\u0631\u0627\u06cc \u0633\u0646\u062f\u0631\u0645 \u0644\u06cc\u0646\u0686 \u06a9\u0645\u06a9\u200c\u06a9\u0646\u0646\u062f\u0647 \u0628\u0627\u0634\u062f \u3010II, B\u3011<\/li><li style=\"text-align: right;\">\u0648 \u0647\u0645\u0686\u0646\u06cc\u0646 \u0628\u0647\u200c\u0639\u0646\u0648\u0627\u0646 \u0628\u062e\u0634\u06cc \u0627\u0632 \u0628\u0631\u0631\u0633\u06cc \u0627\u0648\u0644\u06cc\u0647 \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0645\u062a\u0627\u0633\u062a\u0627\u062a\u06cc\u06a9 \u0628\u0631\u0627\u06cc \u067e\u06cc\u0634\u200c\u0628\u06cc\u0646\u06cc \u067e\u0627\u0633\u062e \u0628\u0647 \u0645\u0647\u0627\u0631\u06a9\u0646\u0646\u062f\u0647\u200c\u0647\u0627\u06cc \u0627\u06cc\u0645\u0646\u06cc (Immune checkpoint inhibitors) \u062a\u0648\u0635\u06cc\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f \u3010I, A\u3011.<\/li><li style=\"text-align: right;\">\u0634\u0646\u0627\u0633\u0627\u06cc\u06cc <b>\u0627\u0641\u0632\u0627\u06cc\u0634 \u0628\u06cc\u0627\u0646<\/b> HER2 (\u0628\u0627 IHC<b>)<\/b> \u0648\/\u06cc\u0627 \u062a\u06a9\u062b\u06cc\u0631 \u0698\u0646 HER2 (ESCAT: II-B) \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 <b>RAS-WT <\/b><b>(<\/b><b>\u0628\u062f\u0648\u0646 <\/b><b>\u062c\u0647\u0634 \u062f\u0631 \u0698\u0646<\/b> <b>RAS<\/b><b>)<\/b> \u062a\u0648\u0635\u06cc\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f\u060c \u0628\u0631\u0627\u06cc \u062a\u0634\u062e\u06cc\u0635 \u0627\u0641\u0631\u0627\u062f\u06cc \u06a9\u0647 \u0645\u0645\u06a9\u0646 \u0627\u0633\u062a \u0627\u0632 \u062f\u0631\u0645\u0627\u0646 \u0647\u062f\u0641\u0645\u0646\u062f \u0633\u0648\u062f \u0628\u0628\u0631\u0646\u062f.<\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0667f3f e-con-full e-flex e-con e-child\" data-id=\"0667f3f\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1f2448e e-flex e-con-boxed e-con e-parent\" data-id=\"1f2448e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-352b722 e-con-full e-flex e-con e-child\" data-id=\"352b722\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a886bf0 e-con-full e-flex e-con e-child\" data-id=\"a886bf0\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5de7838 elementor-widget elementor-widget-text-editor\" data-id=\"5de7838\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p style=\"text-align: right;\">\u062f\u0631 \u0635\u0648\u0631\u062a\u06cc \u06a9\u0647 NGS \u0686\u0646\u062f\u0698\u0646\u06cc \u062a\u0648\u0645\u0648\u0631 \u062f\u0631 \u062f\u0633\u062a\u0631\u0633 \u0648 \u0642\u0627\u0628\u0644 \u0627\u062c\u0631\u0627 \u0628\u0627\u0634\u062f\u060c \u062a\u0648\u0635\u06cc\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f \u0622\u0632\u0645\u0627\u06cc\u0634 \u0628\u0631\u0627\u06cc \u0645\u0648\u0627\u0631\u062f \u0632\u06cc\u0631 \u0627\u0646\u062c\u0627\u0645 \u0634\u0648\u062f:<\/p><ul><li style=\"text-align: right;\"><b>KRAS G12C<\/b> (I, A\u061b ESCAT: I-A)<\/li><li style=\"text-align: right;\"><b>\u062c\u0647\u0634\u200c\u0647\u0627\u06cc <\/b><b>POLE<\/b> (III, C\u061b ESCAT: II-B)<\/li><li style=\"text-align: right;\">\u0648 \u0646\u06cc\u0632 \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u0698\u0646\u0648\u0645\u06cc \u06a9\u0647 \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0647\u062f\u0641\u0645\u0646\u062f \u0628\u0631\u0627\u06cc \u0622\u0646\u0647\u0627 \u062f\u0631 \u0627\u0646\u062f\u06cc\u06a9\u0627\u0633\u06cc\u0648\u0646 \u062a\u0648\u0645\u0648\u0631-\u0627\u06af\u0646\u0648\u0633\u062a\u06cc\u06a9 \u062a\u0623\u06cc\u06cc\u062f \u0634\u062f\u0647\u200c\u0627\u0646\u062f (\u0645\u0627\u0646\u0646\u062f: \u062a\u0631\u06a9\u06cc\u0628\u200c\u0647\u0627\u06cc NTRK\u060c \u062a\u0631\u06a9\u06cc\u0628\u200c\u0647\u0627\u06cc RET\u060c TMB-H\u061b (ESCAT: I-C)) \u3010III, C\u3011.<\/li><li style=\"text-align: right;\">\u0622\u0632\u0645\u0627\u06cc\u0634 \u0633\u0627\u06cc\u0631 \u0628\u06cc\u0648\u0645\u0627\u0631\u06a9\u0631\u0647\u0627 \u0627\u0632 \u062c\u0645\u0644\u0647:<\/li><li style=\"text-align: right;\"><b>\u062a\u0631\u06a9\u06cc\u0628\u200c\u0647\u0627\u06cc \u0698\u0646\u06cc <\/b><b>ALK <\/b><b>\u0648 <\/b><b>ROS1<\/b> (ESCAT: III-A)<\/li><li style=\"text-align: right;\"><b>\u062c\u0647\u0634\u200c\u0647\u0627\u06cc <\/b><b>PIK3CA<\/b><\/li><li style=\"text-align: right;\"><b>\u062c\u0647\u0634\u200c\u0647\u0627\u06cc \u0641\u0639\u0627\u0644\u200c\u06a9\u0646\u0646\u062f\u0647 <\/b><b>HER2<\/b><br \/>\u062e\u0627\u0631\u062c \u0627\u0632 \u0686\u0627\u0631\u0686\u0648\u0628 \u06a9\u0627\u0631\u0622\u0632\u0645\u0627\u06cc\u06cc\u200c\u0647\u0627\u06cc \u0628\u0627\u0644\u06cc\u0646\u06cc \u062a\u0648\u0635\u06cc\u0647 \u0646\u0645\u06cc\u200c\u0634\u0648\u062f. (IV, D)<\/li><li style=\"text-align: right;\">\u067e\u06cc\u0634 \u0627\u0632 \u0634\u0631\u0648\u0639 \u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc \u0645\u0628\u062a\u0646\u06cc \u0628\u0631 <b>5-<\/b><b>FU<\/b>\u060c \u0627\u0646\u062c\u0627\u0645 \u062a\u0633\u062a \u0628\u0631\u0627\u06cc <b>\u06a9\u0645\u0628\u0648\u062f \u0622\u0646\u0632\u06cc\u0645 \u062f\u06cc\u200c\u0647\u06cc\u062f\u0631\u0648\u067e\u06cc\u0631\u06cc\u0645\u06cc\u062f\u06cc\u0646 \u062f\u0647\u06cc\u062f\u0631\u0648\u0698\u0646\u0627\u0632 (<\/b><b>DPD deficiency<\/b><b>)<\/b>\u0627\u0644\u0632\u0627\u0645\u06cc \u0627\u0633\u062a. (III, A)<\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-db076e5 e-con-full e-flex e-con e-child\" data-id=\"db076e5\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u062a\u0634\u062e\u06cc\u0635\u060c \u067e\u0627\u062a\u0648\u0644\u0648\u0698\u06cc \u0648 \u0632\u06cc\u0633\u062a\u200c\u0634\u0646\u0627\u0633\u06cc \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc \u0628\u0631\u0627\u06cc \u0622\u0632\u0645\u0627\u06cc\u0634\u200c\u0647\u0627\u06cc \u0646\u0634\u0627\u0646\u06af\u0631 \u0632\u06cc\u0633\u062a\u06cc (Biomarker) \u062a\u0648\u0635\u06cc\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f \u06a9\u0647 \u0646\u0645\u0648\u0646\u0647\u200c\u0647\u0627 \u0628\u0627 \u0641\u0631\u0645\u0627\u0644\u06cc\u0646 \u0628\u0627\u0641\u0631\u06cc \u062e\u0646\u062b\u06cc \u06f1\u06f0\u066a (\u0645\u0639\u0627\u062f\u0644 \u06f4\u066a \u0641\u0631\u0645\u0627\u0644\u062f\u0647\u06cc\u062f) \u062a\u062b\u0628\u06cc\u062a \u0634\u0648\u0646\u062f\u061b \u0645\u062f\u062a \u062a\u062b\u0628\u06cc\u062a \u0646\u0628\u0627\u06cc\u062f \u06a9\u0645\u062a\u0631 \u0627\u0632 \u06f6 \u0633\u0627\u0639\u062a \u0648 \u0628\u06cc\u0634\u062a\u0631 \u0627\u0632 \u06f4\u06f8 \u0633\u0627\u0639\u062a \u0628\u0627\u0634\u062f. (\u062f\u0631\u062c\u0647 \u062a\u0648\u0635\u06cc\u0647: V, A) \u067e\u0627\u062a\u0648\u0644\u0648\u0698\u06cc\u0633\u062a \u0627\u0635\u0644\u06cc \u0628\u0627\u06cc\u062f \u062a\u0645\u0627\u0645 \u0646\u0645\u0648\u0646\u0647\u200c\u0647\u0627\u06cc \u062a\u0648\u0645\u0648\u0631\u06cc \u0645\u0648\u062c\u0648\u062f \u0631\u0627 \u0628\u0631\u0631\u0633\u06cc \u06a9\u0646\u062f \u0648 \u0628\u0631\u0627\u06cc \u0627\u0641\u0632\u0627\u06cc\u0634 \u0645\u062d\u062a\u0648\u0627\u06cc [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-4365","post","type-post","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"https:\/\/gimed.ir\/Colorectal-cancer\/wp-json\/wp\/v2\/posts\/4365","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gimed.ir\/Colorectal-cancer\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gimed.ir\/Colorectal-cancer\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gimed.ir\/Colorectal-cancer\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/gimed.ir\/Colorectal-cancer\/wp-json\/wp\/v2\/comments?post=4365"}],"version-history":[{"count":11,"href":"https:\/\/gimed.ir\/Colorectal-cancer\/wp-json\/wp\/v2\/posts\/4365\/revisions"}],"predecessor-version":[{"id":4401,"href":"https:\/\/gimed.ir\/Colorectal-cancer\/wp-json\/wp\/v2\/posts\/4365\/revisions\/4401"}],"wp:attachment":[{"href":"https:\/\/gimed.ir\/Colorectal-cancer\/wp-json\/wp\/v2\/media?parent=4365"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gimed.ir\/Colorectal-cancer\/wp-json\/wp\/v2\/categories?post=4365"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gimed.ir\/Colorectal-cancer\/wp-json\/wp\/v2\/tags?post=4365"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}