{"id":2693,"date":"2024-11-26T22:50:34","date_gmt":"2024-11-26T19:20:34","guid":{"rendered":"https:\/\/gimed.ir\/Colorectal-cancer\/?page_id=2693"},"modified":"2024-12-05T13:05:01","modified_gmt":"2024-12-05T09:35:01","slug":"triple-negative-breast-cancer","status":"publish","type":"page","link":"https:\/\/gimed.ir\/Colorectal-cancer\/triple-negative-breast-cancer\/","title":{"rendered":"Triple-negative Breast Cancer\u200b"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2693\" class=\"elementor elementor-2693\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a6be0f6 e-flex e-con-boxed e-con e-parent\" data-id=\"a6be0f6\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f29f6ca e-con-full e-flex e-con e-child\" data-id=\"f29f6ca\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-f07f680 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data-widget_type=\"hotspot.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"530\" src=\"https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2024\/11\/fig5.jpg\" class=\"attachment-large size-large wp-image-2609\" alt=\"\" srcset=\"https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2024\/11\/fig5.jpg 937w, https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2024\/11\/fig5-500x331.jpg 500w, https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2024\/11\/fig5-300x199.jpg 300w, https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2024\/11\/fig5-768x509.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\n\t\t\t\t\t\t<div class=\"e-hotspot elementor-repeater-item-6490865  e-hotspot--position-right e-hotspot--position-top   e-hotspot--icon\">\n\n\t\t\t\t\t\t\t\t<div class=\"e-hotspot__button e-hotspot--soft-beat\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__icon\"><svg class=\"e-font-icon-svg e-fas-info-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z\"><\/path><\/svg><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__tooltip  e-hotspot--tooltip-position e-hotspot--fade-in-out \" >\n\t\t\t\t\t\t<ol><li>\u0627\u06af\u0631 PD-L1 \u0645\u062b\u0628\u062a \u0628\u0627\u0634\u062f\u060c \u06af\u0632\u06cc\u0646\u0647 \u062a\u0631\u062c\u06cc\u062d\u06cc ChT \u062f\u0631 \u062a\u0631\u06a9\u06cc\u0628 \u0628\u0627 ICI \u0627\u0633\u062a:<\/li><li>\u062f\u0631 \u0635\u0648\u0631\u062a \u0645\u062b\u0628\u062a \u0628\u0648\u062f\u0646 PD-L1 (Ventana SP142)\u060c \u0622\u062a\u0632\u0648\u0644\u06cc\u0632\u0648\u0645\u0627\u0628 \u0628\u0647 \u0647\u0645\u0631\u0627\u0647 \u0646\u0627\u0628-\u067e\u0627\u06a9\u0644\u06cc\u062a\u0627\u06a9\u0633\u0644 \u0647\u0646\u06af\u0627\u0645\u06cc \u06a9\u0647 DFI \u226512 \u0645\u0627\u0647 \u0627\u0633\u062a \u0648 \u062f\u0631 \u06a9\u0634\u0648\u0631\u0647\u0627\u06cc\u06cc \u06a9\u0647 \u0627\u06cc\u0646 \u0627\u0646\u062f\u06cc\u06a9\u0627\u0633\u06cc\u0648\u0646 \u062a\u0627\u06cc\u06cc\u062f \u0634\u062f\u0647.<\/li><li>\u062f\u0631 \u0645\u0648\u0627\u0631\u062f CPS \u226510\u060c \u067e\u0645\u0628\u0631\u0648\u0644\u06cc\u0632\u0648\u0645\u0627\u0628 \u0628\u0647 \u0639\u0644\u0627\u0648\u0647 \u067e\u0627\u06a9\u0644\u06cc \u062a\u0627\u06a9\u0633\u0644\u060c \u0646\u0627\u0628-\u067e\u0627\u06a9\u0644\u06cc\u062a\u0627\u06a9\u0633\u0644 \u06cc\u0627 \u06a9\u0631\u0628\u0648\u067e\u0644\u0627\u062a\u06cc\u0646-\u062c\u0645\u0633\u06cc\u062a\u0627\u0628\u06cc\u0646 \u0647\u0646\u06af\u0627\u0645\u06cc \u06a9\u0647 DFI \u00a0\u2265 6 \u0645\u0627\u0647 \u0627\u0633\u062a. <img decoding=\"async\" class=\"alignnone size-medium wp-image-2705\" src=\"https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2024\/11\/56-500x72.png\" alt=\"\" width=\"500\" height=\"72\" srcset=\"https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2024\/11\/56-500x72.png 500w, https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2024\/11\/56-300x43.png 300w, https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2024\/11\/56.png 673w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/li><\/ol>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\n\t\n\t\t\t\t\t\t<div class=\"e-hotspot elementor-repeater-item-0190d61  e-hotspot--position-right e-hotspot--position-top   e-hotspot--icon\">\n\n\t\t\t\t\t\t\t\t<div class=\"e-hotspot__button e-hotspot--soft-beat\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__icon\"><svg class=\"e-font-icon-svg e-fas-info-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z\"><\/path><\/svg><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__tooltip  e-hotspot--tooltip-position e-hotspot--fade-in-out \" >\n\t\t\t\t\t\t<ol><li>\u0627\u06af\u0631 \u067e\u0631\u0648\u0641\u0627\u06cc\u0644 \u0628\u0647 \u0635\u0648\u0631\u062a gBRCAm \u0648 PD-L1-\u0645\u0646\u0641\u06cc \u0628\u0627\u0634\u062f\u060c \u06af\u0632\u06cc\u0646\u0647 \u0647\u0627\u06cc \u062a\u0631\u062c\u06cc\u062d\u06cc \u0627\u0648\u0644\u0627\u067e\u0627\u0631\u06cc\u0628 \u06cc\u0627 \u062a\u0627\u0644\u0627\u0632\u0648\u067e\u0627\u0631\u06cc\u0628 \u06cc\u0627 ChT \u0628\u0627 \u06a9\u0631\u0628\u0648\u067e\u0644\u0627\u062a\u06cc\u0646 \u0647\u0633\u062a\u0646\u062f.<\/li><\/ol><p>\u00a0<\/p><p><img decoding=\"async\" class=\"alignnone size-medium wp-image-3086\" src=\"https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2024\/12\/57.png\" alt=\"\" width=\"469\" height=\"89\" srcset=\"https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2024\/12\/57.png 469w, https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2024\/12\/57-300x57.png 300w\" sizes=\"(max-width: 469px) 100vw, 469px\" \/><\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\n\t\n\t\t\t\t\t\t<div class=\"e-hotspot elementor-repeater-item-3a1fc6d  e-hotspot--position-right e-hotspot--position-top   e-hotspot--icon\">\n\n\t\t\t\t\t\t\t\t<div class=\"e-hotspot__button e-hotspot--soft-beat\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__icon\"><svg class=\"e-font-icon-svg e-fas-info-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z\"><\/path><\/svg><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__tooltip  e-hotspot--tooltip-position e-hotspot--fade-in-out \" >\n\t\t\t\t\t\t<ol><li>\u0627\u06af\u0631 \u067e\u0631\u0648\u0641\u0627\u06cc\u0644 \u0628\u0647 \u0635\u0648\u0631\u062a PD-L1-\u0645\u0646\u0641\u06cc \u0648 gBRCA \u0628\u0627\u0634\u062f\u060c \u06af\u0632\u06cc\u0646\u0647 \u0627\u0631\u062c\u062d \u0628\u0633\u062a\u06af\u06cc \u0628\u0647 \u0645\u0648\u0627\u062c\u0647\u0647 \u0642\u0628\u0644\u06cc \u0628\u0627 \u062f\u0631\u0645\u0627\u0646\u060c \u0627\u0631\u0627\u0626\u0647 \u0628\u06cc\u0645\u0627\u0631\u06cc\u060c DFI \u0648 \u0645\u0644\u0627\u062d\u0638\u0627\u062a \u0628\u06cc\u0645\u0627\u0631 \u062f\u0627\u0631\u062f:<\/li><li>\u062a\u06a9 \u062f\u0631\u0645\u0627\u0646\u06cc \u062a\u0627\u06a9\u0633\u0627\u0646 \u0631\u0627\u06cc\u062c \u062a\u0631\u06cc\u0646 \u06af\u0632\u06cc\u0646\u0647 \u0627\u0633\u062a<\/li><li>\u062f\u0631 \u0635\u0648\u0631\u062a \u0639\u062f\u0645 \u0645\u0648\u0627\u062c\u0647\u0647 \u0642\u0628\u0644\u06cc \u06cc\u0627 \u062f\u0631 \u0635\u0648\u0631\u062a \u0627\u0645\u06a9\u0627\u0646 \u0686\u0627\u0644\u0634 \u0645\u062c\u062f\u062f\u060c \u0622\u0646\u062a\u0631\u0627\u0633\u0627\u06cc\u06a9\u0644\u06cc\u0646 \u0647\u0627 \u06cc\u06a9 \u06af\u0632\u06cc\u0646\u0647 \u0647\u0633\u062a\u0646\u062f<\/li><li>\u062f\u0631 \u0635\u0648\u0631\u062a \u0646\u0627\u0631\u0633\u0627\u06cc\u06cc \u0642\u0631\u06cc\u0628 \u0627\u0644\u0648\u0642\u0648\u0639 \u0627\u0646\u062f\u0627\u0645\u060c \u062f\u0631\u0645\u0627\u0646 \u062a\u0631\u06a9\u06cc\u0628\u06cc \u0628\u0631 \u0627\u0633\u0627\u0633 \u062a\u0631\u06a9\u06cc\u0628 \u062a\u0627\u06a9\u0633\u0627\u0646 \u0648\/\u06cc\u0627 \u0622\u0646\u062a\u0631\u0627\u0633\u06cc\u06a9\u0644\u06cc\u0646 \u0648 \u0634\u0627\u0645\u0644 \u0628\u0648\u0627\u0633\u06cc\u0632\u0648\u0645\u0627\u0628 (\u0641\u0642\u0637 \u062e\u0637 \u0627\u0648\u0644)\u060c \u062f\u0631 \u0635\u0648\u0631\u062a \u0648\u062c\u0648\u062f\u060c \u062a\u0631\u062c\u06cc\u062d \u062f\u0627\u062f\u0647 \u0645\u06cc \u0634\u0648\u062f.<\/li><\/ol>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\n\t\n\t\t\t\t\t\t<div class=\"e-hotspot elementor-repeater-item-d52dce7  e-hotspot--position-right e-hotspot--position-top   e-hotspot--icon\">\n\n\t\t\t\t\t\t\t\t<div class=\"e-hotspot__button e-hotspot--soft-beat\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__icon\"><svg class=\"e-font-icon-svg e-fas-info-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z\"><\/path><\/svg><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__tooltip  e-hotspot--tooltip-position e-hotspot--fade-in-out \" >\n\t\t\t\t\t\t<p style=\"text-align: center;\"><strong>Sacituzumab govitecan-hziy (mTNBC)\u200b<\/strong><\/p><ol><li>Sacituzumab (\u062f\u0631 \u0635\u0648\u0631\u062a \u0645\u0648\u062c\u0648\u062f \u0628\u0648\u062f\u0646) \u06af\u0632\u06cc\u0646\u0647 \u062f\u0631\u0645\u0627\u0646\u06cc \u0627\u0631\u062c\u062d \u067e\u0633 \u0627\u0632 ChT \u0642\u0628\u0644\u06cc \u0627\u0633\u062a.<img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-3087\" src=\"https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2024\/12\/62-500x34.png\" alt=\"\" width=\"500\" height=\"34\" srcset=\"https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2024\/12\/62-500x34.png 500w, https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2024\/12\/62-300x20.png 300w, https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2024\/12\/62.png 635w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><p style=\"text-align: center;\"><strong>Trastuzumab Deruxtecan for HER2-low<\/strong><\/p><\/li><li><p style=\"text-align: right;\">\u00a0Trastuzumab deruxtecan \u0628\u0627\u06cc\u062f \u0628\u0631\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 HER2-low \u067e\u0633 \u0627\u0632 \u062d\u062f\u0627\u0642\u0644 \u06cc\u06a9 \u062e\u0637 ChT \u062f\u0631 \u0646\u0638\u0631 \u06af\u0631\u0641\u062a\u0647 \u0634\u0648\u062f. <img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-3088\" src=\"https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2024\/12\/63-500x40.png\" alt=\"\" width=\"500\" height=\"40\" srcset=\"https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2024\/12\/63-500x40.png 500w, https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2024\/12\/63-300x24.png 300w, https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2024\/12\/63.png 600w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/p><\/li><\/ol><p style=\"text-align: center;\"><strong>Further Lines with Chemotherapy (mTNBC)\u200b<\/strong><\/p><p>\u00a0 \u00a0 3. \u067e\u0633 \u0627\u0632 \u067e\u06cc\u0634\u0631\u0641\u062a\u060c \u062a\u0645\u0627\u0645 \u062a\u0648\u0635\u06cc\u0647 \u0647\u0627\u06cc ChT \u0628\u0631\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u06cc HER2- \u0645\u0646\u0641\u06cc \u0628\u0631\u0627\u06cc TNBC \u0645\u0627\u0646\u0646\u062f \u0627\u0631\u06cc\u0628\u0648\u0644\u06cc\u0646\u060c \u06a9\u067e\u0633\u06cc\u062a\u0627\u0628\u06cc\u0646 \u0648 \u0648\u06cc\u0646\u0648\u0631\u0644\u0628\u06cc\u0646 \u0646\u06cc\u0632 \u0627\u0639\u0645\u0627\u0644 \u0645\u06cc \u0634\u0648\u062f.<\/p><p>\u00a0 \u00a0 4. \u0647\u06cc\u0686 \u062f\u0627\u062f\u0647\u200c\u0627\u06cc \u0628\u0631\u0627\u06cc \u062d\u0645\u0627\u06cc\u062a \u0627\u0632 \u062f\u0631\u0645\u0627\u0646 \u0622\u0646\u062a\u06cc \u0622\u0646\u062f\u0631\u0648\u0698\u0646 \u06cc\u0627 \u0645\u0647\u0627\u0631\u06a9\u0646\u0646\u062f\u0647\u200c\u0647\u0627\u06cc\u06cc \u06a9\u0647 PI3K\u060c HER2 \u06cc\u0627 AKT \u0631\u0627 \u0628\u0631\u0627\u06cc TNBC \u067e\u06cc\u0634\u0631\u0641\u062a\u0647 \u0647\u062f\u0641 \u0642\u0631\u0627\u0631 \u0645\u06cc\u200c\u062f\u0647\u0646\u062f \u0648\u062c\u0648\u062f \u0646\u062f\u0627\u0631\u062f \u0648 \u0628\u0646\u0627\u0628\u0631\u0627\u06cc\u0646 \u0646\u0645\u06cc\u200c\u062a\u0648\u0627\u0646 \u0622\u0646\u0647\u0627 \u0631\u0627 \u0628\u0631\u0627\u06cc \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0645\u0639\u0645\u0648\u0644 \u062e\u0627\u0631\u062c \u0627\u0632 \u06cc\u06a9 \u06a9\u0627\u0631\u0622\u0632\u0645\u0627\u06cc\u06cc \u0628\u0627\u0644\u06cc\u0646\u06cc \u062a\u0648\u0635\u06cc\u0647 \u06a9\u0631\u062f.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\n\t\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f03a73b e-con-full e-flex e-con e-child\" data-id=\"f03a73b\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0e660a4 e-flex e-con-boxed e-con e-parent\" data-id=\"0e660a4\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-66bc1b0 e-con-full e-flex e-con e-child\" data-id=\"66bc1b0\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-29b0848 e-con-full e-flex e-con e-child\" data-id=\"29b0848\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c280251 elementor-view-default elementor-widget elementor-widget-icon\" data-id=\"c280251\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-info-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d1e2a07 elementor-widget elementor-widget-text-editor\" data-id=\"d1e2a07\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p style=\"text-align: left;\">ChT, chemotherapy; EMA, European Medicines Agency; ESCAT, ESMO Scale for Clinical Actionability of Molecular Targets; FDA, Food and Drug Administration;\u00a0<em>gBRCAm<\/em>, germline\u00a0<em>BRCA1\/2<\/em>\u00a0mutation; ICI, immune checkpoint inhibitor; MCBS, ESMO-Magnitude of Clinical Benefit Scale; mTNBC, metastatic triple-negative breast cancer; PARP, poly (ADP-ribose) polymerase; PD-L1, programmed death-ligand 1.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-be984b5 e-con-full e-flex e-con e-child\" data-id=\"be984b5\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u0627\u06af\u0631 PD-L1 \u0645\u062b\u0628\u062a \u0628\u0627\u0634\u062f\u060c \u06af\u0632\u06cc\u0646\u0647 \u062a\u0631\u062c\u06cc\u062d\u06cc ChT \u062f\u0631 \u062a\u0631\u06a9\u06cc\u0628 \u0628\u0627 ICI \u0627\u0633\u062a: \u062f\u0631 \u0635\u0648\u0631\u062a \u0645\u062b\u0628\u062a \u0628\u0648\u062f\u0646 PD-L1 (Ventana SP142)\u060c \u0622\u062a\u0632\u0648\u0644\u06cc\u0632\u0648\u0645\u0627\u0628 \u0628\u0647 \u0647\u0645\u0631\u0627\u0647 \u0646\u0627\u0628-\u067e\u0627\u06a9\u0644\u06cc\u062a\u0627\u06a9\u0633\u0644 \u0647\u0646\u06af\u0627\u0645\u06cc \u06a9\u0647 DFI \u226512 \u0645\u0627\u0647 \u0627\u0633\u062a \u0648 \u062f\u0631 \u06a9\u0634\u0648\u0631\u0647\u0627\u06cc\u06cc \u06a9\u0647 \u0627\u06cc\u0646 \u0627\u0646\u062f\u06cc\u06a9\u0627\u0633\u06cc\u0648\u0646 \u062a\u0627\u06cc\u06cc\u062f \u0634\u062f\u0647. \u062f\u0631 \u0645\u0648\u0627\u0631\u062f CPS \u226510\u060c \u067e\u0645\u0628\u0631\u0648\u0644\u06cc\u0632\u0648\u0645\u0627\u0628 \u0628\u0647 \u0639\u0644\u0627\u0648\u0647 \u067e\u0627\u06a9\u0644\u06cc \u062a\u0627\u06a9\u0633\u0644\u060c \u0646\u0627\u0628-\u067e\u0627\u06a9\u0644\u06cc\u062a\u0627\u06a9\u0633\u0644 \u06cc\u0627 \u06a9\u0631\u0628\u0648\u067e\u0644\u0627\u062a\u06cc\u0646-\u062c\u0645\u0633\u06cc\u062a\u0627\u0628\u06cc\u0646 \u0647\u0646\u06af\u0627\u0645\u06cc \u06a9\u0647 DFI \u00a0\u2265 6 \u0645\u0627\u0647 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