{"id":2602,"date":"2024-11-26T02:07:47","date_gmt":"2024-11-25T22:37:47","guid":{"rendered":"https:\/\/gimed.ir\/Colorectal-cancer\/?page_id=2602"},"modified":"2025-02-24T21:09:22","modified_gmt":"2025-02-24T17:39:22","slug":"frailty-and-or-comorbidities","status":"publish","type":"page","link":"https:\/\/gimed.ir\/Colorectal-cancer\/frailty-and-or-comorbidities\/","title":{"rendered":"Frailty and\/or Comorbidities"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2602\" class=\"elementor elementor-2602\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-41ddc08 e-con-full e-flex e-con e-parent\" data-id=\"41ddc08\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-642e88d elementor-widget elementor-widget-spacer\" data-id=\"642e88d\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c0954bd e-flex e-con-boxed e-con e-parent\" data-id=\"c0954bd\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-96b1ba6 e-con-full e-flex e-con e-child\" data-id=\"96b1ba6\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d9e5071 e-con-full e-flex e-con e-child\" data-id=\"d9e5071\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3f0dbd0 elementor-widget elementor-widget-hotspot\" data-id=\"3f0dbd0\" data-element_type=\"widget\" data-settings=\"{&quot;hotspot&quot;:[{&quot;_id&quot;:&quot;6490865&quot;,&quot;hotspot_icon&quot;:{&quot;value&quot;:&quot;fas fa-info-circle&quot;,&quot;library&quot;:&quot;fa-solid&quot;},&quot;hotspot_custom_size&quot;:&quot;&quot;,&quot;hotspot_tooltip_content&quot;:&quot;&lt;h4 style=\\&quot;text-align: center;\\&quot;&gt;\\u0628\\u06cc\\u0645\\u0627\\u0631\\u0627\\u0646 \\u0636\\u0639\\u06cc\\u0641 \\u0648\\\/\\u06cc\\u0627 \\u062f\\u0627\\u0631\\u0627\\u06cc \\u0628\\u06cc\\u0645\\u0627\\u0631\\u06cc\\u200c\\u0647\\u0627\\u06cc \\u0647\\u0645\\u0631\\u0627\\u0647&lt;\\\/h4&gt;&lt;ul&gt;&lt;li&gt;\\u062a\\u0639\\u06cc\\u06cc\\u0646 \\u0648\\u0636\\u0639\\u06cc\\u062a \\u062c\\u0647\\u0634RAS \\u0627\\u0632 \\u0637\\u0631\\u06cc\\u0642 \\u0646\\u0645\\u0648\\u0646\\u0647\\u200c\\u0628\\u0631\\u062f\\u0627\\u0631\\u06cc \\u062a\\u0648\\u0645\\u0648\\u0631 [I, A] (\\u06cc\\u0627 \\u0627\\u0632 \\u0637\\u0631\\u06cc\\u0642 \\u0646\\u0645\\u0648\\u0646\\u0647\\u200c\\u0628\\u0631\\u062f\\u0627\\u0631\\u06cc \\u0645\\u0627\\u06cc\\u0639 \\u062f\\u0631 \\u0635\\u0648\\u0631\\u062a \\u0639\\u062f\\u0645 \\u062f\\u0633\\u062a\\u0631\\u0633\\u06cc \\u0628\\u0647 \\u0646\\u0645\\u0648\\u0646\\u0647 \\u062a\\u0648\\u0645\\u0648\\u0631 [II, B]) \\u0628\\u0631\\u0627\\u06cc \\u0647\\u062f\\u0627\\u06cc\\u062a \\u0628\\u0647\\u062a\\u0631\\u06cc\\u0646 \\u062a\\u0635\\u0645\\u06cc\\u0645 \\u062f\\u0631\\u0645\\u0627\\u0646\\u06cc \\u0627\\u0644\\u0632\\u0627\\u0645\\u06cc \\u0627\\u0633\\u062a.\\u00a0&lt;\\\/li&gt;&lt;li&gt;\\u062f\\u0631 \\u0628\\u06cc\\u0645\\u0627\\u0631\\u0627\\u0646\\u06cc \\u06a9\\u0647 \\u062f\\u0627\\u0631\\u0627\\u06cc \\u0628\\u06cc\\u0645\\u0627\\u0631\\u06cc\\u200c\\u0647\\u0627\\u06cc \\u0647\\u0645\\u0631\\u0627\\u0647\\u060c \\u0633\\u0646 \\u0628\\u0627\\u0644\\u0627 \\u06cc\\u0627 \\u0628\\u06cc\\u0645\\u0627\\u0631\\u06cc \\u0645\\u062a\\u0627\\u0633\\u062a\\u0627\\u062a\\u06cc\\u06a9 \\u0647\\u0633\\u062a\\u0646\\u062f \\u06a9\\u0647 \\u0642\\u0627\\u0628\\u0644 \\u062f\\u0631\\u0645\\u0627\\u0646 \\u0628\\u0647 \\u0631\\u0648\\u0634\\u200c\\u0647\\u0627\\u06cc \\u0642\\u0637\\u0639\\u06cc \\u0646\\u0628\\u0648\\u062f\\u0647 \\u0648 \\u0639\\u0644\\u0627\\u0626\\u0645 \\u0642\\u0627\\u0628\\u0644 \\u062a\\u0648\\u062c\\u0647\\u06cc \\u0627\\u0632 \\u0628\\u06cc\\u0645\\u0627\\u0631\\u06cc \\u0646\\u062f\\u0627\\u0631\\u0646\\u062f\\u060c \\u0627\\u0633\\u062a\\u0641\\u0627\\u062f\\u0647 \\u0627\\u0632 \\u062f\\u0631\\u0645\\u0627\\u0646 \\u062a\\u06a9\\u200c\\u062f\\u0627\\u0631\\u0648\\u06cc\\u06cc \\u0628\\u0627 \\u0641\\u0644\\u0648\\u0631\\u0648\\u067e\\u06cc\\u0631\\u0645\\u06cc\\u062f\\u06cc\\u0646 \\u00b1 \\u0628\\u0648\\u0627\\u0633\\u06cc\\u0632\\u0648\\u0645\\u0627\\u0628 \\u0642\\u0627\\u0628\\u0644 \\u0627\\u0633\\u062a\\u0641\\u0627\\u062f\\u0647 \\u0627\\u0633\\u062a [I, B]. \\u062f\\u0631 \\u0628\\u06cc\\u0645\\u0627\\u0631\\u0627\\u0646 \\u0636\\u0639\\u06cc\\u0641 \\u06cc\\u0627 \\u0645\\u0633\\u0646 \\u06a9\\u0647 \\u0642\\u0627\\u062f\\u0631 \\u0628\\u0647 \\u062a\\u062d\\u0645\\u0644 \\u0634\\u06cc\\u0645\\u06cc\\u200c\\u062f\\u0631\\u0645\\u0627\\u0646\\u06cc \\u0646\\u06cc\\u0633\\u062a\\u0646\\u062f \\u0648 \\u062a\\u0648\\u0645\\u0648\\u0631\\u0647\\u0627\\u06cc\\u0634\\u0627\\u0646 \\u0633\\u0645\\u062a \\u0686\\u067e \\u0648 RAS-wt \\u0627\\u0633\\u062a\\u060c \\u062f\\u0631\\u0645\\u0627\\u0646 \\u062a\\u06a9\\u200c\\u062f\\u0627\\u0631\\u0648\\u06cc\\u06cc \\u0628\\u0627 \\u0622\\u0646\\u062a\\u06cc\\u200c\\u0628\\u0627\\u062f\\u06cc\\u200c\\u0647\\u0627\\u06cc \\u0645\\u0648\\u0646\\u0648\\u06a9\\u0644\\u0648\\u0646\\u0627\\u0644 \\u0636\\u062f-EGFR \\u0645\\u06cc\\u200c\\u062a\\u0648\\u0627\\u0646\\u062f \\u062f\\u0631 \\u0646\\u0638\\u0631 \\u06af\\u0631\\u0641\\u062a\\u0647 \\u0634\\u0648\\u062f [IV, C].&lt;\\\/li&gt;&lt;li&gt;\\u062f\\u0631 \\u0628\\u06cc\\u0645\\u0627\\u0631\\u0627\\u0646\\u06cc \\u06a9\\u0647 \\u062f\\u0631 \\u0627\\u062b\\u0631 \\u0634\\u06cc\\u0645\\u06cc\\u200c\\u062f\\u0631\\u0645\\u0627\\u0646\\u06cc \\u0645\\u0628\\u062a\\u0646\\u06cc \\u0628\\u0631 5-FU \\u06cc\\u0627 \\u06a9\\u0627\\u067e\\u0633\\u06cc\\u062a\\u0627\\u0628\\u06cc\\u0646 \\u062f\\u0686\\u0627\\u0631 \\u0633\\u0645\\u06cc\\u062a \\u0642\\u0644\\u0628\\u06cc \\u0648\\\/\\u06cc\\u0627 \\u0633\\u0646\\u062f\\u0631\\u0645 \\u062f\\u0633\\u062a \\u0648 \\u067e\\u0627 \\u0634\\u062f\\u0647\\u200c\\u0627\\u0646\\u062f\\u060c \\u0645\\u06cc\\u200c\\u062a\\u0648\\u0627\\u0646 \\u0627\\u0632S-1 \\u0628\\u0647 \\u0639\\u0646\\u0648\\u0627\\u0646 \\u062c\\u0627\\u06cc\\u06af\\u0632\\u06cc\\u0646 \\u0627\\u0633\\u062a\\u0641\\u0627\\u062f\\u0647 \\u06a9\\u0631\\u062f [III, B].&lt;\\\/li&gt;&lt;\\\/ul&gt;&quot;,&quot;hotspot_offset_x&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:52,&quot;sizes&quot;:[]},&quot;hotspot_offset_y&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:26,&quot;sizes&quot;:[]},&quot;hotspot_tooltip_position&quot;:&quot;yes&quot;,&quot;hotspot_position&quot;:&quot;top&quot;,&quot;hotspot_tooltip_width&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:409,&quot;sizes&quot;:[]},&quot;hotspot_tooltip_text_wrap&quot;:&quot;yes&quot;,&quot;hotspot_label&quot;:&quot;&quot;,&quot;hotspot_link&quot;:{&quot;url&quot;:&quot;&quot;,&quot;is_external&quot;:&quot;&quot;,&quot;nofollow&quot;:&quot;&quot;,&quot;custom_attributes&quot;:&quot;&quot;},&quot;hotspot_horizontal&quot;:&quot;right&quot;,&quot;hotspot_vertical&quot;:&quot;top&quot;}],&quot;tooltip_position&quot;:&quot;right&quot;,&quot;hotspot_sequenced_animation&quot;:&quot;no&quot;,&quot;tooltip_trigger&quot;:&quot;click&quot;,&quot;tooltip_animation&quot;:&quot;e-hotspot--fade-in-out&quot;}\" data-widget_type=\"hotspot.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"728\" height=\"482\" src=\"https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2025\/02\/Picture1.png\" class=\"attachment-large size-large wp-image-4092\" alt=\"\" srcset=\"https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2025\/02\/Picture1.png 728w, https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2025\/02\/Picture1-500x331.png 500w, https:\/\/gimed.ir\/Colorectal-cancer\/wp-content\/uploads\/2025\/02\/Picture1-300x199.png 300w\" sizes=\"(max-width: 728px) 100vw, 728px\" \/>\n\t\t\t\t\t\t<div class=\"e-hotspot elementor-repeater-item-6490865  e-hotspot--position-right e-hotspot--position-top   e-hotspot--icon\">\n\n\t\t\t\t\t\t\t\t<div class=\"e-hotspot__button e-hotspot--soft-beat\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__icon\"><svg class=\"e-font-icon-svg e-fas-info-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z\"><\/path><\/svg><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__tooltip  e-hotspot--tooltip-position e-hotspot--fade-in-out \" >\n\t\t\t\t\t\t<h4 style=\"text-align: center;\">\u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0636\u0639\u06cc\u0641 \u0648\/\u06cc\u0627 \u062f\u0627\u0631\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u06cc\u200c\u0647\u0627\u06cc \u0647\u0645\u0631\u0627\u0647<\/h4><ul><li>\u062a\u0639\u06cc\u06cc\u0646 \u0648\u0636\u0639\u06cc\u062a \u062c\u0647\u0634RAS \u0627\u0632 \u0637\u0631\u06cc\u0642 \u0646\u0645\u0648\u0646\u0647\u200c\u0628\u0631\u062f\u0627\u0631\u06cc \u062a\u0648\u0645\u0648\u0631 [I, A] (\u06cc\u0627 \u0627\u0632 \u0637\u0631\u06cc\u0642 \u0646\u0645\u0648\u0646\u0647\u200c\u0628\u0631\u062f\u0627\u0631\u06cc \u0645\u0627\u06cc\u0639 \u062f\u0631 \u0635\u0648\u0631\u062a \u0639\u062f\u0645 \u062f\u0633\u062a\u0631\u0633\u06cc \u0628\u0647 \u0646\u0645\u0648\u0646\u0647 \u062a\u0648\u0645\u0648\u0631 [II, B]) \u0628\u0631\u0627\u06cc \u0647\u062f\u0627\u06cc\u062a \u0628\u0647\u062a\u0631\u06cc\u0646 \u062a\u0635\u0645\u06cc\u0645 \u062f\u0631\u0645\u0627\u0646\u06cc \u0627\u0644\u0632\u0627\u0645\u06cc \u0627\u0633\u062a.\u00a0<\/li><li>\u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646\u06cc \u06a9\u0647 \u062f\u0627\u0631\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u06cc\u200c\u0647\u0627\u06cc \u0647\u0645\u0631\u0627\u0647\u060c \u0633\u0646 \u0628\u0627\u0644\u0627 \u06cc\u0627 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0645\u062a\u0627\u0633\u062a\u0627\u062a\u06cc\u06a9 \u0647\u0633\u062a\u0646\u062f \u06a9\u0647 \u0642\u0627\u0628\u0644 \u062f\u0631\u0645\u0627\u0646 \u0628\u0647 \u0631\u0648\u0634\u200c\u0647\u0627\u06cc \u0642\u0637\u0639\u06cc \u0646\u0628\u0648\u062f\u0647 \u0648 \u0639\u0644\u0627\u0626\u0645 \u0642\u0627\u0628\u0644 \u062a\u0648\u062c\u0647\u06cc \u0627\u0632 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0646\u062f\u0627\u0631\u0646\u062f\u060c \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u062f\u0631\u0645\u0627\u0646 \u062a\u06a9\u200c\u062f\u0627\u0631\u0648\u06cc\u06cc \u0628\u0627 \u0641\u0644\u0648\u0631\u0648\u067e\u06cc\u0631\u0645\u06cc\u062f\u06cc\u0646 \u00b1 \u0628\u0648\u0627\u0633\u06cc\u0632\u0648\u0645\u0627\u0628 \u0642\u0627\u0628\u0644 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0633\u062a [I, B]. \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0636\u0639\u06cc\u0641 \u06cc\u0627 \u0645\u0633\u0646 \u06a9\u0647 \u0642\u0627\u062f\u0631 \u0628\u0647 \u062a\u062d\u0645\u0644 \u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc \u0646\u06cc\u0633\u062a\u0646\u062f \u0648 \u062a\u0648\u0645\u0648\u0631\u0647\u0627\u06cc\u0634\u0627\u0646 \u0633\u0645\u062a \u0686\u067e \u0648 RAS-wt \u0627\u0633\u062a\u060c \u062f\u0631\u0645\u0627\u0646 \u062a\u06a9\u200c\u062f\u0627\u0631\u0648\u06cc\u06cc \u0628\u0627 \u0622\u0646\u062a\u06cc\u200c\u0628\u0627\u062f\u06cc\u200c\u0647\u0627\u06cc \u0645\u0648\u0646\u0648\u06a9\u0644\u0648\u0646\u0627\u0644 \u0636\u062f-EGFR \u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u062f \u062f\u0631 \u0646\u0638\u0631 \u06af\u0631\u0641\u062a\u0647 \u0634\u0648\u062f [IV, C].<\/li><li>\u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646\u06cc \u06a9\u0647 \u062f\u0631 \u0627\u062b\u0631 \u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc \u0645\u0628\u062a\u0646\u06cc \u0628\u0631 5-FU \u06cc\u0627 \u06a9\u0627\u067e\u0633\u06cc\u062a\u0627\u0628\u06cc\u0646 \u062f\u0686\u0627\u0631 \u0633\u0645\u06cc\u062a \u0642\u0644\u0628\u06cc \u0648\/\u06cc\u0627 \u0633\u0646\u062f\u0631\u0645 \u062f\u0633\u062a \u0648 \u067e\u0627 \u0634\u062f\u0647\u200c\u0627\u0646\u062f\u060c \u0645\u06cc\u200c\u062a\u0648\u0627\u0646 \u0627\u0632S-1 \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u062c\u0627\u06cc\u06af\u0632\u06cc\u0646 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u06a9\u0631\u062f [III, B].<\/li><\/ul>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\n\t\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f388b57 e-con-full e-flex e-con e-child\" data-id=\"f388b57\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-66265ef e-flex e-con-boxed e-con e-parent\" data-id=\"66265ef\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e69efe6 elementor-widget elementor-widget-spacer\" data-id=\"e69efe6\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-35adc15 e-flex e-con-boxed e-con e-parent\" data-id=\"35adc15\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-9fe15e0 e-con-full e-flex e-con e-child\" data-id=\"9fe15e0\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4e3689c e-con-full e-flex e-con e-child\" data-id=\"4e3689c\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-18d4f99 elementor-view-default elementor-widget elementor-widget-icon\" data-id=\"18d4f99\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-info-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7b944a5 elementor-widget elementor-widget-text-editor\" data-id=\"7b944a5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p style=\"text-align: left;\">Purple: general categories or stratification; blue: systemic anticancer therapy; white: other aspects of management<\/p><p style=\"text-align: left;\">5-FU, 5-fluorouracil; ChT, chemotherapy; EGFR, epidermal growth factor receptor; mCRC, metastatic colorectal cancer; PD, progressive disease; S-1, tegafur\u2013gimeracil\u2013oteracil; wt, wild-type<\/p><p style=\"text-align: left;\">(a) In patients presenting with cardiotoxicity and\/or hand-foot syndrome on 5-FU or capecitabine-based ChT, S-1 may be used as an alternative [III, B]<\/p><p style=\"text-align: left;\">(b) Additional details on treatments and drug combinations can be found under the section \u2018Management of advanced and metastatic disease without potential conversion\u2019 (subsections \u2018First-line treatment\u2019 and \u2018Second-line treatment\u2019)<\/p><p style=\"text-align: left;\">(c) In patients unable to tolerate ChT whose tumours are left-sided and RAS-wt<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d936c17 e-con-full e-flex e-con e-child\" data-id=\"d936c17\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0636\u0639\u06cc\u0641 \u0648\/\u06cc\u0627 \u062f\u0627\u0631\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u06cc\u200c\u0647\u0627\u06cc \u0647\u0645\u0631\u0627\u0647 \u062a\u0639\u06cc\u06cc\u0646 \u0648\u0636\u0639\u06cc\u062a \u062c\u0647\u0634RAS \u0627\u0632 \u0637\u0631\u06cc\u0642 \u0646\u0645\u0648\u0646\u0647\u200c\u0628\u0631\u062f\u0627\u0631\u06cc \u062a\u0648\u0645\u0648\u0631 [I, A] (\u06cc\u0627 \u0627\u0632 \u0637\u0631\u06cc\u0642 \u0646\u0645\u0648\u0646\u0647\u200c\u0628\u0631\u062f\u0627\u0631\u06cc \u0645\u0627\u06cc\u0639 \u062f\u0631 \u0635\u0648\u0631\u062a \u0639\u062f\u0645 \u062f\u0633\u062a\u0631\u0633\u06cc \u0628\u0647 \u0646\u0645\u0648\u0646\u0647 \u062a\u0648\u0645\u0648\u0631 [II, B]) \u0628\u0631\u0627\u06cc \u0647\u062f\u0627\u06cc\u062a \u0628\u0647\u062a\u0631\u06cc\u0646 \u062a\u0635\u0645\u06cc\u0645 \u062f\u0631\u0645\u0627\u0646\u06cc \u0627\u0644\u0632\u0627\u0645\u06cc \u0627\u0633\u062a.\u00a0 \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646\u06cc \u06a9\u0647 \u062f\u0627\u0631\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u06cc\u200c\u0647\u0627\u06cc \u0647\u0645\u0631\u0627\u0647\u060c \u0633\u0646 \u0628\u0627\u0644\u0627 \u06cc\u0627 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0645\u062a\u0627\u0633\u062a\u0627\u062a\u06cc\u06a9 \u0647\u0633\u062a\u0646\u062f \u06a9\u0647 \u0642\u0627\u0628\u0644 \u062f\u0631\u0645\u0627\u0646 \u0628\u0647 \u0631\u0648\u0634\u200c\u0647\u0627\u06cc \u0642\u0637\u0639\u06cc \u0646\u0628\u0648\u062f\u0647 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2602","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/gimed.ir\/Colorectal-cancer\/wp-json\/wp\/v2\/pages\/2602","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gimed.ir\/Colorectal-cancer\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/gimed.ir\/Colorectal-cancer\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/gimed.ir\/Colorectal-cancer\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/gimed.ir\/Colorectal-cancer\/wp-json\/wp\/v2\/comments?post=2602"}],"version-history":[{"count":62,"href":"https:\/\/gimed.ir\/Colorectal-cancer\/wp-json\/wp\/v2\/pages\/2602\/revisions"}],"predecessor-version":[{"id":4096,"href":"https:\/\/gimed.ir\/Colorectal-cancer\/wp-json\/wp\/v2\/pages\/2602\/revisions\/4096"}],"wp:attachment":[{"href":"https:\/\/gimed.ir\/Colorectal-cancer\/wp-json\/wp\/v2\/media?parent=2602"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}